LAQV-REQUIMTE & Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
CESAM & Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal.
Molecules. 2021 Jul 15;26(14):4292. doi: 10.3390/molecules26144292.
The development of novel anticancer agents is essential to finding new ways to treat this disease, one of the deadliest diseases. Some marine organisms have proved to be important producers of chemically active compounds with valuable bioactive properties, including anticancer. Thus, the ocean has proved to be a huge source of bioactive compounds, making the discovery and study of these compounds a growing area. In the last few years, several compounds of marine origin, which include algae, corals, and sea urchins, have been isolated, studied, and demonstrated to possess anticancer properties. These compounds, mainly from securamines and sterols families, have been tested for cytotoxic/antiproliferative activity in different cell lines. Bioactive compounds isolated from marine organisms in the past 5 years that have shown anticancer activity, emphasizing the ones that showed the highest cytotoxic activity, such as securamines H and I, cholest-3β,5α,6β-triol, ()-24-methylcholest-22-ene-3β,5α,6β-triol, 24-methylenecholesta-3β,5α,6β-triol, and 24-methylcholesta-3β,5α,6β-triol, will be discussed in this review. These studies reveal the possibility of new compounds of marine origin being used as new therapeutic agents or as a source of inspiration to develop new therapeutic agents.
新型抗癌药物的开发对于寻找治疗这种致命疾病的新方法至关重要。一些海洋生物已被证明是具有有价值生物活性的化学活性化合物的重要生产者，包括抗癌化合物。因此，海洋已被证明是生物活性化合物的巨大来源，使这些化合物的发现和研究成为一个不断发展的领域。在过去的几年中，已经从藻类、珊瑚和海胆等海洋生物中分离、研究并证明了几种具有抗癌特性的海洋来源化合物。这些化合物主要来自于 securamines 和甾醇家族，已在不同的细胞系中测试其细胞毒性/抗增殖活性。本文将重点讨论过去 5 年中从海洋生物中分离出的具有抗癌活性的生物活性化合物，强调那些具有最高细胞毒性活性的化合物，如 securamines H 和 I、胆甾-3β,5α,6β-三醇、()-24-甲基胆甾-22-烯-3β,5α,6β-三醇、24-亚甲基胆甾-3β,5α,6β-三醇和 24-甲基胆甾-3β,5α,6β-三醇。这些研究揭示了新型海洋来源化合物作为新的治疗剂或开发新治疗剂的灵感来源的可能性。
