School of Medicine, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan.
Department of General Surgery, E-Da Cancer Hospital, Kaohsiung 82445, Taiwan.
Int J Environ Res Public Health. 2021 Jul 20;18(14):7696. doi: 10.3390/ijerph18147696.
In this large-scale prospective cohort study, a propensity score matching method was applied in a natural experimental design to investigate how post-acute care (PAC) after stroke affects functional status and to identify predictors of functional status. The main objective of this study was to examine longitudinal changes in various measures of functional status in stroke patients and predictors of scores for these measures before and after PAC. A group of patients who had received PAC for stroke at one of two medical centers (PAC group, = 273) was compared with a group who had received standard care for stroke at one of four hospitals (three regional hospital and one district hospital; non-PAC group, = 273) in Taiwan from March, 2014, to October, 2018. The patients completed the functional status measures before rehabilitation, the 12th week and the 1st year after rehabilitation. Generalized estimating equations were used to estimate differences-in-differences models for examining the effects of PAC. The average age was 68.0 (SD = 8.1) years, and males accounted for 57.9%. During the follow-up period, significant risk factors for poor functional outcomes were advanced age, hemorrhagic stroke, and poor function scores before rehabilitation ( < 0.05). Between-group comparisons at subsequent time points revealed significantly higher functional status scores in the PAC group versus the non-PAC group ( < 0.001). Notably, for all functional status measures, between-group differences in total scores significantly increased over time from baseline to 1 year post-rehabilitation ( < 0.001). The contribution of this study is its further elucidation of the clinical implications and health policy implications of rehabilitative care after stroke. Specifically, it improves understanding of the effects of PAC in stroke patients at different follow-up times. Therefore, a policy implication of this study is that standard care for stroke should include intensive rehabilitative PAC to maximize recovery of overall function.
在这项大规模的前瞻性队列研究中,采用倾向评分匹配方法进行自然实验设计,以研究急性后期护理(PAC)对卒中患者功能状态的影响,并确定功能状态的预测因素。本研究的主要目的是检查卒中患者各种功能状态测量指标的纵向变化,以及 PAC 前后这些测量指标评分的预测因素。2014 年 3 月至 2018 年 10 月,在台湾的两家医疗机构(PAC 组,n = 273)为卒中患者提供 PAC,与四家医院(三家区域医院和一家地区医院;非-PAC 组,n = 273)为卒中患者提供标准护理进行比较。患者在康复前、第 12 周和第 1 年完成功能状态测量。采用广义估计方程估计差异-差异模型,以检验 PAC 的效果。平均年龄为 68.0(SD = 8.1)岁,男性占 57.9%。在随访期间,功能预后不良的显著危险因素为年龄较大、出血性卒中以及康复前功能评分较差(<0.05)。在随后的时间点进行的组间比较显示,PAC 组的功能状态评分显著高于非-PAC 组(<0.001)。值得注意的是,对于所有功能状态测量,从基线到康复后 1 年,组间总分差异随时间显著增加(<0.001)。本研究的贡献在于进一步阐明了卒中后康复护理的临床意义和卫生政策意义。具体而言,它提高了对不同随访时间卒中患者 PAC 影响的理解。因此,本研究的一个政策意义是,卒中的标准护理应包括强化康复 PAC,以最大限度地恢复整体功能。