Adzet T, Camarasa J, Laguna J C
Departamento de Farmacognosia y Farmacodinamia, Facultad de Farmacia, Núcleo Universitario de Pedralbes, Barcelona, Spain.
J Nat Prod. 1987 Jul-Aug;50(4):612-7. doi: 10.1021/np50052a004.
The hepatoprotective activity against CCl4 toxicity in isolated rat hepatocytes of some polyphenolic compounds, such as cynarin, isochlorogenic acid, chlorogenic acid, luteolin-7-glucoside, and two organic acids, caffeic and quinic, from Cynara scolymus, is tested. Only cynarine and, to a lesser extent, caffeic acid showed cytoprotective action. The possible relationship between the molecular structure and the protective effect found is discussed.
测试了一些多酚类化合物，如绿原酸、异绿原酸、咖啡酸、木犀草素 - 7 - 葡萄糖苷以及来自菊苣的两种有机酸咖啡酸和奎尼酸，对分离的大鼠肝细胞中四氯化碳毒性的肝保护活性。只有绿原酸以及程度稍低的咖啡酸表现出细胞保护作用。讨论了所发现的分子结构与保护作用之间可能的关系。
