Universidad Científica del Sur, Lima, Peru.
Department of Epidemiology and Bisotatistics, School of Public Health, Imperial College London, London, UK.
BMJ Open. 2021 Jul 23;11(7):e050409. doi: 10.1136/bmjopen-2021-050409.
To estimate the pooled prevalence of multimorbidity (≥2 non-communicable diseases in the same individual) among adults of the general population of Latin American and the Caribbean (LAC).
Systematic review and meta-analysis.
MEDLINE, Embase, Global Health, Scopus and LILACS up to 1 July 2020.
The outcome was the prevalence of multimorbidity. Reports were selected whether they enrolled adult individuals (age ≥18 years) from the general population.
Reviewers extracted relevant data and assessed risk of bias independently. A random-effects meta-analysis was conducted to report pooled prevalence estimates of multimorbidity; pooled estimates by pre-specified subgroups (eg, national studies) were also pursued.
From 5830 results, we selected 28 reports, mostly from Brazil and 16 were based on a nationally representative sample. From the 28 selected reports, 26 were further included in the meta-analysis revealing a pooled multimorbidity prevalence of 43% (95% CI: 35% to 51%; I: 99.9%). When only reports with a nationally representative sample were combined, the pooled prevalence was 37% (95% CI: 27% to 47%; I: 99.9%). When the ascertainment of multimorbidity was based on self-reports alone, the pooled prevalence was 40% (95% CI: 31% to 48%; I: 99.9%); this raised to 52% (95% CI: 33% to 70%; I: 99.9%) for reports including self-reported and objective diagnosis.
Our results complement and advance those from global efforts by incorporating much more reports from LAC. We revealed a larger presence of multimorbidity in LAC than previously reported.
CRD42020196177.
估计拉丁美洲和加勒比地区（LAC）一般人群中成年人多种疾病（同一人患有 2 种及以上非传染性疾病）的患病率。
系统评价和荟萃分析。
截至 2020 年 7 月 1 日，MEDLINE、Embase、全球健康、Scopus 和 LILACS。
结局为多种疾病的患病率。报告纳入了一般人群中的成年个体（年龄≥18 岁）。
审查员独立提取相关数据并评估偏倚风险。采用随机效应荟萃分析报告多种疾病的汇总患病率估计值；还进行了按预先指定的亚组（例如，全国性研究）的汇总估计值。
从 5830 项结果中，我们选择了 28 份报告，这些报告主要来自巴西，其中 16 项基于全国代表性样本。在 28 份入选报告中，有 26 份进一步纳入荟萃分析，结果显示多种疾病的汇总患病率为 43%（95%CI：35%至 51%；I²：99.9%）。当仅结合具有全国代表性样本的报告时，汇总患病率为 37%（95%CI：27%至 47%；I²：99.9%）。当多种疾病的确定仅基于自我报告时，汇总患病率为 40%（95%CI：31%至 48%；I²：99.9%）；对于包括自我报告和客观诊断的报告，这一比例上升至 52%（95%CI：33%至 70%；I²：99.9%）。
我们的结果补充并推进了全球努力，纳入了更多来自 LAC 的报告。我们揭示了 LAC 中多种疾病的患病率高于先前报告的结果。
PROSPERO 注册号：CRD42020196177。
