Pacheco-Barrios Kevin, Velasquez-Rimachi Victor, Navarro-Flores Alba, Huerta-Rosario Andrely, Morán-Mariños Cristian, Molina Roberto A, Farroñay-García Chandel, Metcalf Tatiana, Fregni Felipe, Alva-Díaz Carlos
Unidad de Investigación para la Generación y Síntesis de Evidencias en Salud, Universidad San Ignacio de Loyola, Lima, Peru.
SYNAPSIS Mental Health and Neurology, Lima, Peru.
Cephalalgia. 2023 Jan;43(1):3331024221128265. doi: 10.1177/03331024221128265.
In this manuscript, we aim to systematically estimate the pooled prevalence and incidence of primary headaches and its subtypes (migraine, tension-type headache, and chronic headaches) in Latin America and the Caribbean, describing its epidemiological profile and associated factors.
We systematically searched PubMed/MEDLINE, Scopus, and LILACS (From conception to March 2021), for populational studies reporting the epidemiology of primary headaches and their associated factors in Latin America and the Caribbean. The data extraction was conducted independently. We performed random-effect model meta-analysis of prevalence (overall primary headaches and by subtypes) and associated factors, assessed potential sources of heterogeneity, the risk of bias, publication bias, and the evidence certainty (GRADE methodology).
We included 32 populational studies (38 subpopulations, n = 63,813). The prevalence of primary headaches was 41.4% (95% CI 31.1-52.2%; n = 54,357), 15% for migraine (95% CI 12.0-18.3; n = 53,658 individuals), 20.6% for tension-type headache (95% CI 12.4-30.2; n = 25,840), and 6% for chronic headaches (95% CI 3.3-9.6; n = 21,720), with high between-study heterogeneity. No incidence data was found. Female sex, white ethnicity, high BMI, comorbid mental health disorders, and low-back pain were associated with higher prevalence of primary headaches. The prevalence was less in rural areas.
In Latin America and the Caribbean, primary headaches are highly prevalent affecting young females disproportionally. The prevalence of chronic headaches is higher than in other systematic global and regional estimations. The presence of comorbidities as modifiable risk factors should encourage their integration as targets for community-based preventive and therapeutic interventions.
CRD42018105116.
在本论文中，我们旨在系统地评估拉丁美洲和加勒比地区原发性头痛及其亚型（偏头痛、紧张型头痛和慢性头痛）的合并患病率和发病率，描述其流行病学特征及相关因素。
我们系统检索了PubMed/MEDLINE、Scopus和LILACS（从创刊至2021年3月），查找报告拉丁美洲和加勒比地区原发性头痛流行病学及其相关因素的人群研究。数据提取由独立人员进行。我们对患病率（总体原发性头痛及其亚型）和相关因素进行随机效应模型荟萃分析，评估异质性的潜在来源、偏倚风险、发表偏倚和证据确定性（GRADE方法）。
我们纳入了32项人群研究（38个亚人群，n = 63,813）。原发性头痛的患病率为41.4%（95%CI 31.1 - 52.2%；n = 54,357），偏头痛为15%（95%CI 12.0 - 18.3；n = 53,658人），紧张型头痛为20.6%（95%CI 12.4 - 30.2；n = 25,840），慢性头痛为6%（95%CI 3.3 - 9.6；n = 21,720），研究间异质性较高。未找到发病率数据。女性、白人种族、高体重指数、合并心理健康障碍和腰痛与原发性头痛的较高患病率相关。农村地区的患病率较低。
在拉丁美洲和加勒比地区，原发性头痛非常普遍，对年轻女性的影响尤为严重。慢性头痛的患病率高于其他全球和区域系统评估。合并症作为可改变的风险因素的存在应促使将其纳入基于社区的预防和治疗干预目标。
CRD42018105116。
