Department of Medical Social Sciences, Northwestern University, Chicago, IL, United States; Institute for Innovations in Developmental Sciences, Northwestern University, Chicago, IL, United States.
Department of Medical Social Sciences, Northwestern University, Chicago, IL, United States; Institute for Innovations in Developmental Sciences, Northwestern University, Chicago, IL, United States.
Neurosci Biobehav Rev. 2021 Oct;129:231-244. doi: 10.1016/j.neubiorev.2021.07.022. Epub 2021 Jul 21.
The National Institute of Mental Health Research Domain Criteria (RDoC) framework promotes the dimensional and transdiagnostic operationalization of psychopathology, but consideration of the neurodevelopmental foundations of mental health problems requires deeper examination. Irritability, the dispositional tendency to angry emotion that has both mood and behavioral elements, is dimensional, transdiagnostic, and observable early in life-a promising target for the identification of early neural indicators or risk factors for psychopathology. Here, we examine functional brain networks linked to irritability from preschool to adulthood and discuss how development and early experience may influence these neural substrates. Functional connectivity measured with fMRI varies according to irritability and indicates the atypical coordination of several functional networks involved in emotion generation, emotion perception, attention, internalization, and cognitive control. We lay out an agenda to improve our understanding and detection of atypical brain:behavior patterns through advances in the characterization of both functional networks and irritability as well as the consideration and operationalization of developmental and early life environmental influences on this pathway.
美国国立精神卫生研究院研究领域标准（RDoC）框架促进了精神病理学的维度和跨诊断操作性定义，但需要更深入地考虑心理健康问题的神经发育基础。易激惹是一种情绪和行为元素兼具的易激惹倾向，它具有维度性、跨诊断性和可在生命早期观察到的特点，是识别精神病理学早期神经指标或风险因素的有前途的目标。在这里，我们从幼儿期到成年期检查与易激惹相关的功能性大脑网络，并讨论发育和早期经验如何影响这些神经基质。使用 fMRI 测量的功能连接会根据易激惹而变化，并表明涉及情绪产生、情绪感知、注意力、内化和认知控制的几个功能网络的不协调。我们提出了一个议程，通过在功能网络和易激惹的特征描述方面的进展，以及对这条途径上的发育和早期生活环境影响的考虑和操作性定义，来改善我们对异常大脑：行为模式的理解和检测。
