MacSweeney Niamh, Louvet Perrine, Zafar Simal, Chan Stella W Y, Kwong Alex S F, Lawrie Stephen M, Romaniuk Liana, Whalley Heather C
Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.
Front Behav Neurosci. 2023 Jun 15;17:1124940. doi: 10.3389/fnbeh.2023.1124940. eCollection 2023.
Irritability is a core symptom of adolescent depression, characterized by an increased proneness to anger or frustration. Irritability in youth is associated with future mental health problems and impaired social functioning, suggesting that it may be an early indicator of emotion regulation difficulties. Adolescence is a period during which behavior is significantly impacted by one's environment. However, existing research on the neural basis of irritability typically use experimental paradigms that overlook the social context in which irritability occurs. Here, we bring together current findings on irritability in adolescent depression and the associated neurobiology and highlight directions for future research. Specifically, we emphasize the importance of co-produced research with young people as a means to improve the construct and ecological validity of research within the field. Ensuring that our research design and methodology accurately reflect to lives of young people today lays a strong foundation upon which to better understand adolescent depression and identify tractable targets for intervention.
易怒是青少年抑郁症的核心症状，其特征是更容易发怒或沮丧。青少年的易怒与未来的心理健康问题和社会功能受损有关，这表明它可能是情绪调节困难的早期指标。青春期是一个人的行为受到环境显著影响的时期。然而，现有的关于易怒神经基础的研究通常使用的实验范式忽略了易怒发生的社会背景。在这里，我们汇总了当前关于青少年抑郁症中易怒及其相关神经生物学的研究结果，并强调了未来研究的方向。具体而言，我们强调与年轻人共同开展研究的重要性，以此作为提高该领域研究的结构效度和生态效度的一种手段。确保我们的研究设计和方法准确反映当今年轻人的生活，为更好地理解青少年抑郁症并确定可处理的干预目标奠定了坚实的基础。
