Department of Biotechnology, SRM University, Delhi-NCR, Sonepat, Haryana 131029, India; Functional Genomics Unit, Institute of Genomics and Integrative Biology, CSIR, Delhi 110007, India.
Functional Genomics Unit, Institute of Genomics and Integrative Biology, CSIR, Delhi 110007, India.
Drug Discov Today. 2021 Nov;26(11):2774-2781. doi: 10.1016/j.drudis.2021.07.012. Epub 2021 Jul 22.
Cellular exposure to extreme environments leads to the expression of multiple proteins that participate in pathophysiological manifestations. Hypobaric hypoxia at high altitude (HA) generates reactive oxygen species (ROS) that can damage telomeres. Tankyrase (TNKS) belongs to multiple telomeric protein complexes and is actively involved in DNA damage repair. Although published research on TNKS indicates its possible role in cancer and other hypoxic diseases, its role in HA sicknesses remains elusive. Understanding the roles of telomeres, telomerase, and TNKS could ameliorate physiological issues experienced at HA. In addition, telomeric TNKS could be a potential biomarker in hypoxia-induced sicknesses or acclimatization. Thus, a new research avenue on TNKS linked to HA sickness might lead to the discovery of drugs for hypobaric hypoxia.
细胞暴露在极端环境中会导致多种参与病理生理表现的蛋白质表达。高海拔（HA）低气压缺氧会产生活性氧（ROS），从而损害端粒。端粒体酶（TNKS）属于多种端粒体蛋白复合物，积极参与 DNA 损伤修复。尽管关于 TNKS 的已发表研究表明其在癌症和其他低氧疾病中可能具有作用，但它在 HA 疾病中的作用仍不清楚。了解端粒、端粒体酶和 TNKS 的作用可以改善在 HA 中经历的生理问题。此外，端粒体 TNKS 可能是缺氧性疾病或适应过程中的潜在生物标志物。因此，与 HA 疾病相关的 TNKS 的新研究途径可能会发现针对低气压缺氧的药物。
