Department of Paediatrics, Shenmu Hospital, School of Life Sciences and Medicine, Northwest University, Guangming Road, Shenmu, China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education. Faculty of Life Sciences, Northwest University, 229 Taibai North Road, Xi'an, China.
Department of Cardiology, Xi'an No.3 Hospital, School of Life Sciences and Medicine, Northwest University, 10 Fengcheng Three Road, Xi'an, China.
Pharmacol Res. 2021 Sep;171:105757. doi: 10.1016/j.phrs.2021.105757. Epub 2021 Jul 21.
Ischemia-reperfusion injury (IRI) is a process whereby an initial ischemia injury and subsequent recovery of blood flow, which leads to the propagation of an innate immune response and the changes of structural and functional of multiple organs. Therefore, IRI is considered to be a great challenge in clinical treatment such as organ transplantation or coronary angioplasty. In recent years, ethyl pyruvate (EP), a derivative of pyruvate, has received great attention because of its stability and low toxicity. Previous studies have proved that EP has various pharmacological activities, including anti-inflammation, anti-oxidative stress, anti-apoptosis, and anti-fibrosis. Compelling evidence has indicated EP plays a beneficial role in a variety of acute injury models, such as brain IRI, myocardial IRI, renal IRI, and hepatic IRI. Moreover, EP can not only effectively inhibit multiple IRI-induced pathological processes, but also improve the structural and functional lesion of tissues and organs. In this study, we review the recent progress in the research on EP and discuss their implications for a better understanding of multiple organ IRI, and the prospects of targeting the EP for therapeutic intervention.
缺血再灌注损伤（IRI）是一种初始缺血损伤和随后恢复血流的过程，导致固有免疫反应的传播和多个器官的结构和功能的变化。因此，IRI 被认为是器官移植或经皮冠状动脉介入治疗等临床治疗中的一个巨大挑战。近年来，丙酮酸乙酯（EP）作为丙酮酸的衍生物，因其稳定性和低毒性而受到广泛关注。先前的研究已经证明 EP 具有多种药理活性，包括抗炎、抗氧化应激、抗细胞凋亡和抗纤维化。令人信服的证据表明 EP 在多种急性损伤模型中发挥有益作用，如脑 IRI、心肌 IRI、肾 IRI 和肝 IRI。此外，EP 不仅能有效抑制多种 IRI 诱导的病理过程，还能改善组织和器官的结构和功能损伤。本研究综述了 EP 研究的最新进展，并讨论了其对深入了解多器官 IRI 的意义，以及针对 EP 进行治疗干预的前景。
