Department of Pharmacy, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.
College of Pharmacy, Dalian Medical University, Dalian 116044, China.
Molecules. 2022 Aug 16;27(16):5227. doi: 10.3390/molecules27165227.
Intestinal ischemia/reperfusion (II/R) injury is a common life-threatening complication with high morbidity and mortality. Chebulae Fructus Immaturus, the unripe fruit of Terminalia chebula Retz., also known as “Xiqingguo” or “Tibet Olive” in China, has been widely used in traditional Tibetan medicine throughout history. The phenolic acids’ extract of Chebulae Fructus Immaturus (XQG for short) has exhibited strong antioxidative, anti-inflammation, anti-apoptosis, and antibacterial activities. However, whether XQG can effectively ameliorate II/R injuries remains to be clarified. Our results showed that XQG could effectively alleviate II/R-induced intestinal morphological damage and intestinal barrier injury by decreasing the oxidative stress, inflammatory response, and cell death. Transcriptomic analysis further revealed that the main action mechanism of XQG protecting against II/R injury was involved in activating PPARα and inhibiting the NF-κB-signaling pathway. Our study suggests the potential usage of XQG as a new candidate to alleviate II/R injury.
肠缺血/再灌注（II/R）损伤是一种常见的危及生命的并发症，具有高发病率和死亡率。诃子未成熟果实，即诃子的未成熟果实，在中国也被称为“西青果”或“西藏橄榄”，在藏医传统中被广泛应用。诃子未成熟果实的酚酸提取物（简称 XQG）具有很强的抗氧化、抗炎、抗凋亡和抗菌活性。然而，XQG 是否能有效改善 II/R 损伤仍有待阐明。我们的研究结果表明，XQG 通过降低氧化应激、炎症反应和细胞死亡，有效缓解了 II/R 诱导的肠道形态损伤和肠道屏障损伤。转录组分析进一步表明，XQG 保护 II/R 损伤的主要作用机制涉及激活 PPARα 和抑制 NF-κB 信号通路。我们的研究表明，XQG 有作为一种新的候选药物来缓解 II/R 损伤的潜力。
