Physical Examination Center, West China Hospital, Sichuan University, Chengdu 610041, P. R. China.
J Mater Chem B. 2021 Sep 7;9(33):6507-6520. doi: 10.1039/d1tb01121a. Epub 2021 Jul 25.
In the oral environment, the acquired salivary pellicle (ASP) on the tooth surface comprises proteins, glycoproteins, carbohydrates, and lipids. The ASP can specifically and rapidly adsorb on the enamel surface to provide effective lubrication, protection, hydration, and remineralisation, as well as be recognised by various bacteria to form a microbial biofilm (plaque). The involved proteins, particularly various phosphoproteins such as statherins, histatins, and proline-rich proteins, are vital to their specific functions. This review first describes the relationship between the biological functions of these proteins and their structures. Subsequently, recent advances in functional biomedical materials derived from these proteins are reviewed in terms of dental/bone therapeutic materials, antibacterial materials, tissue engineering materials, and coatings for medical devices. Finally, perspectives and challenges regarding the rational design and biomedical applications of ASP-derived materials are discussed.
在口腔环境中，牙齿表面的获得性唾液膜（ASP）由蛋白质、糖蛋白、碳水化合物和脂质组成。ASP 可以特异性和快速地吸附在釉质表面，提供有效的润滑、保护、水合和再矿化作用，并被各种细菌识别，形成微生物生物膜（菌斑）。其中涉及的蛋白质，特别是各种磷蛋白，如唾液蛋白、组蛋白和富含脯氨酸的蛋白质，对其特定功能至关重要。本综述首先描述了这些蛋白质的生物功能与其结构之间的关系。随后，从牙齿/骨骼治疗材料、抗菌材料、组织工程材料和医疗器械涂层等方面，综述了源自这些蛋白质的功能性生物医学材料的最新进展。最后，讨论了 ASP 衍生材料的合理设计和生物医学应用的前景和挑战。
