College of Life Science and Food Engineering, Inner Mongolia University for Nationalities, Tongliao, 028000, China.
Key Laboratory of Bioinformatics of Inner Mongolia University for Nationalities, Tongliao, 028000, China.
Biochem Genet. 2022 Apr;60(2):527-542. doi: 10.1007/s10528-021-10114-2. Epub 2021 Jul 24.
The Cashmere goat (Capra hircus) is renowned for its high-quality fiber production trait. The hair cycle in Cashmere goat has an annual rhythm. To deepen the understanding of the molecular foundation of annual rhythm in the skin of Cashmere goat, we did a comparative analysis of the Cashmere goat skin transcriptome all year round. 4002 Differentially expressed genes (DEGs) were identified with seasonal variations. 12 months transcriptome were divided into four developmental stages: Jan-Mar, Apr-Jul, Aug-Oct, and Nov-Dec based on gene expression patterns. 13 modules of highly correlated genes in skin were identified using WGCNA. Ten of these modules were consistent with the development stages. The gene function of those genes in each module was analyzed by functional enrichment. The results indicated that Wnt and Hedgehog signaling pathways were inhibited from January to March and activated from April to July. The cutaneous immune system of Cashmere goats has high activity from August to October. Fatty acid metabolism dominates goat skin from November to December. This study provides new information related to the annual skin development cycle, which could provide molecular biological significance for understanding the seasonal development and response to the annual rhythm of skin.
绒山羊（Capra hircus）以其高品质的纤维生产特性而闻名。绒山羊的毛发周期具有年度节律。为了深入了解绒山羊皮肤年度节律的分子基础，我们对全年的绒山羊皮肤转录组进行了比较分析。发现有 4002 个差异表达基因（DEGs）具有季节性变化。根据基因表达模式，将 12 个月的转录组分为四个发育阶段：1 月至 3 月、4 月至 7 月、8 月至 10 月和 11 月至 12 月。使用 WGCNA 鉴定了皮肤中 13 个高度相关基因模块。其中 10 个模块与发育阶段一致。通过功能富集分析了每个模块中这些基因的功能。结果表明，Wnt 和 Hedgehog 信号通路从 1 月至 3 月受到抑制，从 4 月至 7 月激活。8 月至 10 月绒山羊的皮肤免疫系统活跃度较高。11 月至 12 月，脂肪酸代谢主导着山羊皮肤的生长。本研究为了解皮肤的季节性发育和对年度节律的反应提供了新的信息，为理解皮肤的年度发育周期提供了分子生物学意义。
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