（±）-内卷素A和B，来自[具体来源未给出]的两对黄烷酮对映体及其对多种癌细胞系增殖的抑制作用。
(±)-Involucrasins A and B, two pairs of flavanone enantiomers from and their inhibitory effects on the proliferation of various cancer cell lines.
作者信息
Liu Lu, Li Xiao-Hong, Ma Xiao-Xia, Tan Wen-Hong, Ma Wen-Zhe, Shen Yun-Fu, Khan Afsar, Zhou Zhi-Hong, Yang Zhu-Ya
机构信息
College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China.
State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
出版信息
J Asian Nat Prod Res. 2022 Jul;24(7):641-647. doi: 10.1080/10286020.2021.1952187. Epub 2021 Jul 24.
(±)-Involucrasins A () and B (), two pairs of flavanone enantiomers were isolated from . Structurally, both and are rare representatives of 5-dehydroxy/5-demethoxy 2',3',4'-trisubstituted flavanones. Their structures were elucidated on the basis of comprehensive spectroscopic data analysis and comparison with the literature data. Involucrasin B () exhibited moderate anti-proliferative activity against Caco-2, MCF-7, MDA-MB-468, and HCT116 cell lines with IC values ranging from 7.9-22.7 μM. Involucrasin A () exhibited weak inhibitory activity against Caco-2 and MCF-7 cell lines with IC values of 25.8 and 26.5 μM, respectively.
从[来源]中分离出了(±)-表儿茶素A（）和B（）这两对黄烷酮对映体。从结构上看，A和B都是5-脱氢/5-脱甲氧基2',3',4'-三取代黄烷酮的罕见代表。它们的结构是在综合光谱数据分析并与文献数据比较的基础上阐明的。表儿茶素B（）对Caco-2、MCF-7、MDA-MB-468和HCT116细胞系表现出中等的抗增殖活性，IC值范围为7.9 - 22.7μM。表儿茶素A（）对Caco-2和MCF-7细胞系表现出较弱的抑制活性，IC值分别为25.8和26.5μM。
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