(±)-内卷素D，一种从[植物名称]根中提取的对映体双黄酮及其抗炎活性。 （注：原文中“from the roots of ”后面缺少具体植物名称）
(±)-Involucrasin D, a pair of enantiomeric bisflavonoid from the roots of and its anti-inflammatory activity.
作者信息
Zhou Xiaoying, Jin Qiong, Zhang Bingruo, Wei Lisha, Bao Lue, Jiang Xiaoyun, Duan Rong, Liu Lu, Yang Zhuya
机构信息
Key Laboratory of Yunnan Provincial Department of Education on Substance Benchmark Research of Ethnic Medicines, Yunnan University of Chinese Medicine, Kunming, China.
出版信息
Nat Prod Res. 2025 Jun;39(11):3172-3180. doi: 10.1080/14786419.2024.2332486. Epub 2024 Apr 8.
An undescribed bisflavonoid, named involucrasin D (), along with two known flavonoids, 2(S)7,3',5'-trihydroxydihydroflavone () and sigmone () were isolated from the roots of . A further chiral separation of to yielded a pair of enantiomers (+)- and (-)-. The structures were elucidated based on spectroscopic analyses and electron circular dichroism (ECD) calculations. Among them, bisflavonoid and its enantiomers displayed remarkable anti-inflammatory effects by inhibiting the production of TNF- and IL-6 in a dose-dependent manner.
从[植物名称]的根部分离出一种未描述的双黄酮，命名为总状紫珠素D（），以及两种已知的黄酮类化合物，2(S)7,3',5'-三羟基二氢黄酮（）和紫珠酮（）。对[化合物名称]进行进一步的手性分离得到一对对映体(+)-和(-)-。通过光谱分析和电子圆二色性（ECD）计算阐明了其结构。其中，双黄酮[化合物名称]及其对映体通过以剂量依赖性方式抑制TNF-和IL-6的产生而表现出显著的抗炎作用。
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