Key Laboratory of Yunnan Provincial Department of Education on Substance Benchmark Research of Ethnic Medicines, Yunnan University of Chinese Medicine, Kunming, 650500, China.
Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan.
Chem Biodivers. 2022 Sep;19(9):e202200188. doi: 10.1002/cbdv.202200188. Epub 2022 Aug 16.
(±)-Involucrasin C (1), a pair of new 2,3-dihydro-1H-indene enantiomers, along with an enantiomeric analog (2), were isolated from Shuteria involucrata. Their structures were established by the basis of comprehensive spectroscopic data analysis and X-ray crystallographic diffraction. Both 1 and 2 significantly inhibited the secretion of pro-inflammatory cytokines IL-6, TNF-α, and IL-1β, suggesting that these two natural 2,3-dihydro-1H-indene derivatives may be active components of S. involucrata and may block inflammation in the initial stage.
（±）- Involucrasin C（1）是一对新的 2,3-二氢-1H-茚的对映异构体，与一个对映体类似物（2）一起从鞘蕊苏中分离得到。它们的结构是通过综合光谱数据分析和 X 射线晶体衍射确定的。1 和 2 均显著抑制促炎细胞因子 IL-6、TNF-α 和 IL-1β 的分泌，表明这两种天然的 2,3-二氢-1H-茚衍生物可能是鞘蕊苏的活性成分，可能阻断炎症的早期阶段。
