甘油三酯/高密度脂蛋白比值与中国成年人糖尿病前期和糖尿病风险的关联：基于开放数据的中国人群队列研究
Associations of TG/HDL Ratio with the Risk of Prediabetes and Diabetes in Chinese Adults: A Chinese Population Cohort Study Based on Open Data.
作者信息
Gong Rongpeng, Liu Yuanyuan, Luo Gang, Liu Wenjing, Jin Ziqi, Xu Zixin, Li Zheng, Yang Lixin, Wei Xiaoxing
机构信息
Medical College of Qinghai University, Xining, Qinghai 810016, China.
Endocrinology Department, Qinghai Provincial People's Hospital, Xining, Qinghai 810007, China.
出版信息
Int J Endocrinol. 2021 Jul 8;2021:9949579. doi: 10.1155/2021/9949579. eCollection 2021.
BACKGROUND
In the global chronic diseases, type 2 diabetes shows a significant upward trend, and there are more people before prediabetes (impaired glucose tolerance). Many patients with impaired glucose tolerance and undiagnosed diabetes do not know that their glucose metabolism system has been in a state of disorder. Every year, about 5% to 10% of prediabetics develop diabetes. One of the important achieving factors may be the increase in blood lipids. However, it is not clear whether the triglyceride/high-density lipoprotein ratio is associated with impaired glucose tolerance and diabetes in the Chinese population. Therefore, we investigated the relationship between triglyceride/high-density lipoprotein and impaired glucose tolerance and diabetes in the Chinese population.
METHODS
We conducted a retrospective cohort study using data from the health screening program. The study included 116,855 participants from 32 locations in China, all of whom were adults over 20. Participants measured fasting blood glucose levels at each visit and collected information about their diabetes history. Impaired glucose tolerance was diagnosed as fasting blood glucose ≥6.00 mmol and self-reported diabetes mellitus. The patient was measured on the date of diagnosis or on his last visit (whichever comes first).
RESULTS
The results showed that, after adjusting the potential confounding factors, the ratio of TG/HDL was positively correlated with the occurrence of prediabetes and diabetes, and there was a saturation effect. The inflection points were 1.04 and 1.33, respectively. The effect value and 95% confidence interval before and after the inflection point of impaired glucose tolerance patients were 1.57 and (1.42, 1.73) and 1.03 and (1.01, 1.05), respectively. The effect value and 95% confidence interval before and after the inflection point in patients with diabetes were 2.07 and (1.80, 2.39) and 1.08 and (1.04, 1.12).
背景
在全球慢性病中，2型糖尿病呈显著上升趋势，且糖尿病前期（糖耐量受损）人群更多。许多糖耐量受损和未确诊糖尿病的患者并不知道其糖代谢系统已处于紊乱状态。每年约5%至10%的糖尿病前期患者会发展为糖尿病。其中一个重要的促成因素可能是血脂升高。然而，在中国人群中，甘油三酯/高密度脂蛋白比值是否与糖耐量受损和糖尿病相关尚不清楚。因此，我们研究了中国人群中甘油三酯/高密度脂蛋白与糖耐量受损及糖尿病之间的关系。
方法
我们利用健康筛查项目的数据进行了一项回顾性队列研究。该研究纳入了来自中国32个地区的116,855名参与者，他们均为20岁以上的成年人。参与者每次就诊时测量空腹血糖水平，并收集其糖尿病病史信息。糖耐量受损被诊断为空腹血糖≥6.00 mmol且自述患有糖尿病。在诊断日期或其最后一次就诊日期（以先到者为准）对患者进行测量。
结果
结果显示，在调整潜在混杂因素后，TG/HDL比值与糖尿病前期和糖尿病的发生呈正相关，且存在饱和效应。拐点分别为1.04和1.33。糖耐量受损患者拐点前后的效应值及95%置信区间分别为1.57和(1.42, 1.73)以及1.03和(1.01, 1.05)。糖尿病患者拐点前后的效应值及95%置信区间分别为2.07和(1.80, 2.39)以及1.08和(1.04, 1.12)。
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