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前列康片对老年慢性前列腺炎患者临床疗效、免疫功能及前列腺液中炎症因子水平的影响

The effect of Qianliekang tablets on the clinical efficacy, immune function, and inflammatory factor levels in the prostatic fluid of elderly chronic prostatitis patients.

作者信息

Yang Chao, Yao Jun, Chen Tianping

机构信息

Urinary Surgery of Wuchang Hospital Affiliated to Wuhan University of Science and Technology Hubei, China.

Emergency Department of Wuchang Hospital Affiliated to Wuhan University of Science and Technology Hubei, China.

出版信息

Am J Transl Res. 2021 Jun 15;13(6):7363-7369. eCollection 2021.

Abstract

PURPOSE

To study the effect of Qianliekang tablets on the clinical efficacy, immune function, and inflammatory factor levels in the prostatic fluid of elderly chronic prostatitis (CP) patients.

METHODS

106 elderly CP patients admitted to our hospital between June 2018 and June 2020 were recruited as the study cohort and randomly divided into a regular group and an observation group. The regular group was administered tamsulosin hydrochloride, and the observation group was administered a combination of tamsulosin hydrochloride and Qianliekang tablets. After a course of treatment, the clinical efficacy, the changes in the patients' symptoms, the function scores, the prostate ultrasound indicators, the changes in the T lymphocyte subsets, and the inflammatory factor expression levels in the prostatic fluid before and after the treatment were measured and compared in the two groups. The occurrence of adverse effects during the treatment was statistically analyzed.

RESULTS

The overall effectiveness rate in the observation group was superior to the overall effectiveness rate in the regular group (94.34% vs. 75.47%, P < 0.05). There were no significant differences in the patient clinical data before the treatment in the two groups (P > 0.05). After the treatment, the CD /CD immune function indicators, the prostatic fluid inflammatory factor levels, the symptom function scores, and the prostate ultrasound indicators in the observation group were better than they were in the regular group (all P < 0.05). No significant differences were found in the incidence of adverse effects between the two groups (P > 0.05).

CONCLUSION

Qianliekang tablets can improve the curative effect in elderly CP patients, enhance their immune function, and reduce the inflammatory factor expression levels in their prostatic fluid.

摘要

目的

探讨前列康片对老年慢性前列腺炎(CP)患者临床疗效、免疫功能及前列腺液中炎症因子水平的影响。

方法

选取2018年6月至2020年6月我院收治的106例老年CP患者作为研究队列,随机分为常规组和观察组。常规组给予盐酸坦索罗辛治疗,观察组给予盐酸坦索罗辛联合前列康片治疗。经过一个疗程的治疗后,测量并比较两组患者的临床疗效、症状变化、功能评分、前列腺超声指标、T淋巴细胞亚群变化以及治疗前后前列腺液中炎症因子表达水平。对治疗期间不良反应的发生情况进行统计学分析。

结果

观察组的总有效率优于常规组(94.34%对75.47%,P<0.05)。两组治疗前患者临床资料比较,差异无统计学意义(P>0.05)。治疗后,观察组的CD/CD免疫功能指标、前列腺液炎症因子水平、症状功能评分及前列腺超声指标均优于常规组(均P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。

结论

前列康片可提高老年CP患者的疗效,增强其免疫功能,降低前列腺液中炎症因子表达水平。

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