Jiang Yuqing, Wang Xiuli, Guo Yuexian, Li Wenping, Yang Shijie, Li Wei, Cai Wenqing
Department of Urology, The Third Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, China (mainland).
Department of Anesthesiology, The Third Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, China (mainland).
Med Sci Monit. 2015 Oct 3;21:2976-85. doi: 10.12659/MSM.894562.
Heat shock protein 27 (HSP 27) is known as a mediator in immune response and has been recently found to be expressed in prostate cancer. This study aimed to investigate the role of HSP27 in inflammatory BPH.
Hospitalized BPH patients who received TURP were divided into 4 groups by the presence and degrees of chronic inflammation: non-inflammatory BPH (NI BPH), mild-inflammatory BPH (MI BPH), moderate-inflammatory BPH (MOI BPH), and severe-inflammatory BPH (SI BPH). Expressions of HSP 27, TNF-α, IL-6, and CD3 in prostate tissues and serum of patients were detected by immunohistochemistry and ELISA.
Expression of HSP27 in BPH with histological inflammation was significantly higher than in non-inflammatory BPH. In inflammatory BPH groups, HSP27 expression gradually increased along with increasing inflammation. There was a significant correlation between the expression of TNF-α, IL-6, CD3 and HSP27 among different inflammatory BPH groups.
HSP27 expression level is associated with the degree of chronic inflammation in BPH and may participate in the pathological process in inflammatory BPH.
热休克蛋白27（HSP 27）被认为是免疫反应中的一种介质，最近发现它在前列腺癌中表达。本研究旨在探讨HSP27在炎性良性前列腺增生（BPH）中的作用。
接受经尿道前列腺切除术（TURP）的住院BPH患者按慢性炎症的有无及程度分为4组：非炎性BPH（NI BPH）、轻度炎性BPH（MI BPH）、中度炎性BPH（MOI BPH）和重度炎性BPH（SI BPH）。采用免疫组织化学和酶联免疫吸附测定（ELISA）法检测患者前列腺组织和血清中HSP 27、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和CD3的表达。
组织学炎症性BPH中HSP27的表达明显高于非炎性BPH。在炎性BPH组中，HSP27表达随炎症加重而逐渐增加。不同炎性BPH组中TNF-α、IL-6、CD3和HSP27的表达之间存在显著相关性。
HSP27表达水平与BPH慢性炎症程度相关，可能参与炎性BPH的病理过程。
