Department of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj 8100, Bangladesh.
Department of Biochemistry and Molecular Biology, Gono University, Dhaka 1344, Bangladesh.
Biomed Res Int. 2021 Jul 1;2021:9050026. doi: 10.1155/2021/9050026. eCollection 2021.
is a thermophilic bacterium that produces a multitude of proteins within its genome. Bioinformatics strategies can facilitate comprehending this organism through functional and structural interpretation assessments. This study is aimed at allocating the structure and function through an approach required for bacterial protein biosynthesis. This viewpoint provides copious properties, including the physicochemical properties, subcellular location, three-dimensional structure, protein-protein interactions, and functional elucidation of the protein (WP_012256288.1). The STRING program is utilized for the explication of protein-protein interactions. The investigation documented the protein's hydrophilic nature with predominantly alpha () helices in its secondary structure. The tertiary-structure model of the protein has been shown to exhibit reasonably high consistency based on various quality assessment methods. The functional interpretation suggested that the protein can act as a translation initiation factor, a protein required for translation and protein biosynthesis. Protein-protein interactions also demonstrated high credence that the protein interconnected with 30S ribosomal subunit involved in protein synthesis. This study bioinformatically examined that the protein (WP_012256288.1) is affiliated in protein biosynthesis as a translation initiation factor IF-3 of .
是一种嗜热细菌，其基因组内产生多种蛋白质。生物信息学策略可以通过功能和结构解释评估来帮助理解该生物体。本研究旨在通过细菌蛋白质生物合成所需的方法分配结构和功能。这种观点提供了丰富的性质，包括蛋白质的理化性质、亚细胞定位、三维结构、蛋白质-蛋白质相互作用和功能阐明（WP_012256288.1）。STRING 程序用于解释蛋白质-蛋白质相互作用。研究记录了该蛋白质具有亲水性，其二级结构中主要为α（）螺旋。该蛋白质的三级结构模型已通过各种质量评估方法显示出相当高的一致性。功能解释表明该蛋白质可以作为翻译起始因子（翻译和蛋白质生物合成所需的蛋白质）发挥作用。蛋白质-蛋白质相互作用也表明，该蛋白质与参与蛋白质合成的 30S 核糖体亚基相互连接的可信度很高。本研究通过生物信息学方法研究了蛋白质（WP_012256288.1）作为翻译起始因子 IF-3 在蛋白质生物合成中的作用。
