Theilgaard Zahra Persson, Chiduo Mercy G, Flamholc Leo, Gerstoft Jan, Bygbjerg Ib C, Lemnge Martha Moshi, Katzenstein Terese L
Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
National Institute for Medical Research, Tanga Centre, Tanga, Tanzania.
East Afr Health Res J. 2019;3(2):88-95. doi: 10.24248/EAHRJ-D-19-00011. Epub 2019 Nov 29.
The success of prevention of mother-to-child transmission (PMTCT) programmes depends on retention of mothers throughout the PMTCT cascade.
In a clinical trial of short-course combination antiretroviral therapy (cART) for PMTCT in Tanzania, senior nurses were employed to reduce the substantial loss-to-follow up (LTFU) rate.
Following intervention, the relative risk (RR) of receiving a CD4 count result and antiretroviral therapy was 1.16 (95% confidence interval [CI], 1.05 to 1.27), the RR of delivery at clinic was 2.51 (95% CI, 2.06 to 3.06), the RR for reporting for follow-up at 6 to 8 weeks postpartum was 4.63 (95% CI, 3.41 to 6.27), and the RR for being retained until 9 months postpartum was 28.19 (95% CI, 11.81 to 67.28). No significant impact on transmission was found.
Significantly higher retention was found after senior nurses were employed. No impact on transmission was found. Relatively low transmission was found in both study arms.
预防母婴传播（PMTCT）项目的成功取决于母亲在整个PMTCT流程中的留存率。
在坦桑尼亚进行的一项关于采用短程联合抗逆转录病毒疗法（cART）预防母婴传播的临床试验中，雇佣了资深护士以降低较高的失访率。
干预后，获得CD4细胞计数结果和接受抗逆转录病毒治疗的相对风险（RR）为1.16（95%置信区间[CI]，1.05至1.27），在诊所分娩的RR为2.51（95%CI，2.06至3.06），产后6至8周进行随访报告的RR为4.63（95%CI，3.41至6.27），留存至产后9个月的RR为28.19（95%CI，11.81至67.28）。未发现对传播有显著影响。
雇佣资深护士后发现留存率显著提高。未发现对传播有影响。两个研究组的传播率均相对较低。
