• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

基于组蛋白去乙酰化酶的透明细胞肾细胞癌新预后标志物的综合分析。

Comprehensive analysis of a new prognosis signature based on histone deacetylases in clear cell renal cell carcinoma.

机构信息

Department of Nephrology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.

Department of Nephrology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

出版信息

Cancer Med. 2021 Sep;10(18):6503-6514. doi: 10.1002/cam4.4156. Epub 2021 Jul 26.

DOI:10.1002/cam4.4156
PMID:34308568
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8446567/
Abstract

Histone deacetylases (HDAC) family is vital for tumorigenesis and tumor progression. However, the exact role of the HDAC family in clear cell renal cell carcinoma (ccRCC) remains unclear. Based on The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC), and The Human Protein Atlas (HPA) database, we investigated and validated the expression profile, clinical significance and prognostic value of HDAC family members in ccRCC. Moreover, we further explored the correlation between HDACs and tumor microenvironment, tumor stemness, drug activity and immune subtype. The HDAC8, HDAC10, and HDAC11 manifested potential clinical value for prognosis, and the correlation analyses reveals underlying molecular mechanisms, which deserve further investigation for ccRCC. This Integrated bioinformatics analysis, based on transcriptomics and proteomics, implied that HDAC8, HDAC10, and HDAC11 may serve as potential molecular biomarkers and therapeutic targets for ccRCC, but some underlying molecular mechanisms still need to be elucidated.

摘要

组蛋白去乙酰化酶（HDAC）家族对肿瘤发生和肿瘤进展至关重要。然而，HDAC 家族在透明细胞肾细胞癌（ccRCC）中的确切作用仍不清楚。基于癌症基因组图谱（TCGA）、国际癌症基因组联盟（ICGC）和人类蛋白质图谱（HPA）数据库，我们研究并验证了 HDAC 家族成员在 ccRCC 中的表达谱、临床意义和预后价值。此外，我们还进一步探讨了 HDACs 与肿瘤微环境、肿瘤干性、药物活性和免疫亚型之间的相关性。HDAC8、HDAC10 和 HDAC11 表现出潜在的预后临床价值，相关性分析揭示了潜在的分子机制，值得进一步研究 ccRCC。这项基于转录组学和蛋白质组学的综合生物信息学分析表明，HDAC8、HDAC10 和 HDAC11 可能作为 ccRCC 的潜在分子生物标志物和治疗靶点，但一些潜在的分子机制仍需要阐明。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba0/8446567/b7602898b1ed/CAM4-10-6503-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba0/8446567/273dd8cede55/CAM4-10-6503-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba0/8446567/8809d6cec2cc/CAM4-10-6503-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba0/8446567/f89a66896a34/CAM4-10-6503-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba0/8446567/25d2e64c2263/CAM4-10-6503-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba0/8446567/29b01c24502e/CAM4-10-6503-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba0/8446567/4306c818f59c/CAM4-10-6503-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba0/8446567/b7602898b1ed/CAM4-10-6503-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba0/8446567/273dd8cede55/CAM4-10-6503-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba0/8446567/8809d6cec2cc/CAM4-10-6503-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba0/8446567/f89a66896a34/CAM4-10-6503-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba0/8446567/25d2e64c2263/CAM4-10-6503-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba0/8446567/29b01c24502e/CAM4-10-6503-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba0/8446567/4306c818f59c/CAM4-10-6503-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba0/8446567/b7602898b1ed/CAM4-10-6503-g006.jpg

相似文献

1
Comprehensive analysis of a new prognosis signature based on histone deacetylases in clear cell renal cell carcinoma.基于组蛋白去乙酰化酶的透明细胞肾细胞癌新预后标志物的综合分析。
Cancer Med. 2021 Sep;10(18):6503-6514. doi: 10.1002/cam4.4156. Epub 2021 Jul 26.
2
Identification of HDAC10 as a candidate oncogene in clear cell renal carcinoma that facilitates tumor proliferation and metastasis.鉴定 HDAC10 为透明细胞肾细胞癌的候选癌基因，促进肿瘤增殖和转移。
Diagn Pathol. 2024 Sep 5;19(1):120. doi: 10.1186/s13000-024-01493-2.
3
High expression levels of DEF6 predicts a poor prognosis for patients with clear cell renal cell carcinoma.DEF6 高表达水平预示着透明细胞肾细胞癌患者的预后不良。
Oncol Rep. 2020 Nov;44(5):2056-2066. doi: 10.3892/or.2020.7736. Epub 2020 Aug 18.
4
Development and validation of a prognostic immune-associated gene signature in clear cell renal cell carcinoma.开发和验证透明细胞肾细胞癌中预后免疫相关基因特征。
Int Immunopharmacol. 2020 Apr;81:106274. doi: 10.1016/j.intimp.2020.106274. Epub 2020 Feb 7.
5
Upregulated GSDMB in Clear Cell Renal Cell Carcinoma Is Associated with Immune Infiltrates and Poor Prognosis.上调的 GSDMB 在透明细胞肾细胞癌中与免疫浸润和不良预后相关。
J Immunol Res. 2021 Dec 16;2021:7753553. doi: 10.1155/2021/7753553. eCollection 2021.
6
Identification of Prognostic Biomarkers for Clear Cell Renal Cell Carcinoma (ccRCC) by Transcriptomics.通过转录组学鉴定透明细胞肾细胞癌（ccRCC）的预后生物标志物。
Ann Clin Lab Sci. 2021 Sep;51(5):597-608.
7
HJURP is a prognostic biomarker for clear cell renal cell carcinoma and is linked to immune infiltration.HJURP 是透明细胞肾细胞癌的预后生物标志物，与免疫浸润有关。
Int Immunopharmacol. 2021 Oct;99:107899. doi: 10.1016/j.intimp.2021.107899. Epub 2021 Jul 1.
8
A novel 10 glycolysis-related genes signature could predict overall survival for clear cell renal cell carcinoma.一种新型的 10 个糖酵解相关基因特征可预测透明细胞肾细胞癌的总生存期。
BMC Cancer. 2021 Apr 9;21(1):381. doi: 10.1186/s12885-021-08111-0.
9
Hexokinase 3 dysfunction promotes tumorigenesis and immune escape by upregulating monocyte/macrophage infiltration into the clear cell renal cell carcinoma microenvironment.己糖激酶 3 功能障碍通过上调单核细胞/巨噬细胞浸润透明细胞肾细胞癌微环境促进肿瘤发生和免疫逃逸。
Int J Biol Sci. 2021 Jun 1;17(9):2205-2222. doi: 10.7150/ijbs.58295. eCollection 2021.
10
Prognostic value of epithelial-mesenchymal transition markers in clear cell renal cell carcinoma.上皮-间充质转化标志物在肾透明细胞癌中的预后价值。
Aging (Albany NY). 2020 Jan 8;12(1):866-883. doi: 10.18632/aging.102660.

引用本文的文献

1
Advances in the study of posttranslational modifications of histones in head and neck squamous cell carcinoma.头颈部鳞状细胞癌中组蛋白翻译后修饰的研究进展。
Clin Epigenetics. 2024 Nov 21;16(1):165. doi: 10.1186/s13148-024-01785-w.
2
Comprehensive Analysis of the Prognostic Implications and Biological Function of HDACs in Liver Hepatocellular Carcinoma.全面分析组蛋白去乙酰化酶在肝肝细胞癌中的预后意义和生物学功能。
Int J Med Sci. 2024 Oct 28;21(14):2807-2823. doi: 10.7150/ijms.97169. eCollection 2024.
3
Identification of HDAC10 as a candidate oncogene in clear cell renal carcinoma that facilitates tumor proliferation and metastasis.

本文引用的文献

1
HDAC11: a rising star in epigenetics.HDAC11：表观遗传学的后起之秀。
Biomed Pharmacother. 2020 Nov;131:110607. doi: 10.1016/j.biopha.2020.110607. Epub 2020 Aug 22.
2
A new survival model based on ferroptosis-related genes for prognostic prediction in clear cell renal cell carcinoma.基于铁死亡相关基因的新型生存模型用于预测透明细胞肾细胞癌的预后。
Aging (Albany NY). 2020 Jul 20;12(14):14933-14948. doi: 10.18632/aging.103553.
3
HDAC10 Regulates Cancer Stem-Like Cell Properties in KRAS-Driven Lung Adenocarcinoma.HDAC10 调控 KRAS 驱动的肺腺癌中的癌症干细胞样细胞特性。
鉴定 HDAC10 为透明细胞肾细胞癌的候选癌基因，促进肿瘤增殖和转移。
Diagn Pathol. 2024 Sep 5;19(1):120. doi: 10.1186/s13000-024-01493-2.
4
Advances in targeting histone deacetylase for treatment of solid tumors.靶向组蛋白去乙酰化酶治疗实体瘤的研究进展。
J Hematol Oncol. 2024 May 31;17(1):37. doi: 10.1186/s13045-024-01551-8.
5
Elevated histone deacetylase 10 expression promotes the progression of clear cell renal cell carcinoma by Notch-1-PTEN signaling axis.组蛋白去乙酰化酶10表达升高通过Notch-1-PTEN信号轴促进透明细胞肾细胞癌进展。
Discov Oncol. 2024 May 11;15(1):156. doi: 10.1007/s12672-024-01018-9.
6
Tumor-associated M2 macrophages in the immune microenvironment influence the progression of renal clear cell carcinoma by regulating M2 macrophage-associated genes.免疫微环境中与肿瘤相关的M2巨噬细胞通过调节M2巨噬细胞相关基因影响肾透明细胞癌的进展。
Front Oncol. 2023 Jun 8;13:1157861. doi: 10.3389/fonc.2023.1157861. eCollection 2023.
7
Exosomal Circsafb2 Reshaping Tumor Environment to Promote Renal Cell Carcinoma Progression by Mediating M2 Macrophage Polarization.外泌体Circsafb2通过介导M2巨噬细胞极化重塑肿瘤微环境以促进肾细胞癌进展。
Front Oncol. 2022 May 12;12:808888. doi: 10.3389/fonc.2022.808888. eCollection 2022.
8
Comprehensive analysis of histone deacetylases genes in the prognosis and immune infiltration of glioma patients.全面分析组蛋白去乙酰化酶基因在胶质瘤患者预后和免疫浸润中的作用。
Aging (Albany NY). 2022 May 11;14(9):4050-4068. doi: 10.18632/aging.204071.
9
Construction and Verification of a Combined Hypoxia and Immune Index for Clear Cell Renal Cell Carcinoma.肾透明细胞癌联合缺氧与免疫指数的构建及验证
Front Genet. 2022 Feb 9;13:711142. doi: 10.3389/fgene.2022.711142. eCollection 2022.
Cancer Res. 2020 Aug 15;80(16):3265-3278. doi: 10.1158/0008-5472.CAN-19-3613. Epub 2020 Jun 15.
4
Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma.体细胞改变与免疫浸润的相互作用调节晚期透明细胞肾细胞癌对 PD-1 阻断的反应。
Nat Med. 2020 Jun;26(6):909-918. doi: 10.1038/s41591-020-0839-y. Epub 2020 May 29.
5
Visualizing and interpreting cancer genomics data via the Xena platform.通过Xena平台可视化和解读癌症基因组学数据。
Nat Biotechnol. 2020 Jun;38(6):675-678. doi: 10.1038/s41587-020-0546-8.
6
HDAC10 Is Positively Associated With PD-L1 Expression and Poor Prognosis in Patients With NSCLC.HDAC10与非小细胞肺癌患者的PD-L1表达及不良预后呈正相关。
Front Oncol. 2020 Apr 21;10:485. doi: 10.3389/fonc.2020.00485. eCollection 2020.
7
Role of HDACs in normal and malignant hematopoiesis.组蛋白去乙酰化酶在正常和恶性造血中的作用。
Mol Cancer. 2020 Jan 7;19(1):5. doi: 10.1186/s12943-019-1127-7.
8
Cancer statistics, 2019.癌症统计数据，2019 年。
CA Cancer J Clin. 2019 Jan;69(1):7-34. doi: 10.3322/caac.21551. Epub 2019 Jan 8.
9
Combination therapy for advanced and metastatic kidney cancer.晚期和转移性肾癌的联合治疗
Nat Rev Urol. 2019 Feb;16(2):77-78. doi: 10.1038/s41585-018-0133-7.
10
HDAC is indispensable for IFN-γ-induced B7-H1 expression in gastric cancer.组蛋白去乙酰化酶对于 IFN-γ 诱导胃癌中 B7-H1 的表达是不可或缺的。
Clin Epigenetics. 2018 Dec 11;10(1):153. doi: 10.1186/s13148-018-0589-6.