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希腊高酚早收特级初榨橄榄油通过基于主导耦合模式（DoCM）模型减少轻度认知障碍患者信息流的过度兴奋：一项 EEG 静息状态验证方法。

Greek High Phenolic Early Harvest Extra Virgin Olive Oil Reduces the Over-Excitation of Information-Flow Based on Dominant Coupling Mode (DoCM) Model in Patients with Mild Cognitive Impairment: An EEG Resting-State Validation Approach.

机构信息

1st Department of Neurology, G.H. "AHEPA, " School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki (AUTH), Thessaloniki, Greece.

Greek Association of Alzheimer's Disease and Related Disorders, Thessaloniki, Makedonia, Greece.

出版信息

J Alzheimers Dis. 2021;83(1):191-207. doi: 10.3233/JAD-210454.

DOI:10.3233/JAD-210454

PMID:34308906

Abstract

BACKGROUND

Extra virgin olive oil (EVOO) constitutes a natural compound with high protection over cognitive function that could positively alter brain dynamics and the mixture of within and between-frequency connectivity.

OBJECTIVE

The balance of cross-frequency coupling over within-frequency coupling can build a nonlinearity index (NI) that encapsulates the over-excitation of information flow between brain areas and across experimental time. The present study investigated for the very first time how the Greek High Phenolic Early Harvest Extra Virgin Olive Oil (HP-EH-EVOO) versus Moderate Phenolic (MP-EVOO) and Mediterranean Diet (MeDi) intervention in people with mild cognitive impairment (MCI) could affect their spontaneous EEG dynamic connectivity.

METHODS

Forty-three subjects (14 in MeDi, 16 in MP-EVOO, and 13 in HP-EH-EVOO) followed an EEG resting-state recording session (eyes-open and closed) before and after the treatment. Following our dominant coupling mode model, we built a dynamic integrated dynamic functional connectivity graph that tabulates the functional strength and the dominant coupling mode model of every pair of brain areas.

RESULTS

Signal spectrum within 1-13 Hz and theta/beta ratio have decreased in the HP-EH-EVOO group in the eyes-open condition. The intervention improved the FIDoCM across groups and conditions but was more prominent in the HP-EH-EVOO group (p < 0.001). Finally, we revealed a significant higher post-intervention reduction of NI (ΔNITotal and α) for the HP-EH-EVOO compared to the MP-EVOO and MeDi groups (p < 0.0001).

CONCLUSION

Long-term intervention with HP-EH-EVOO reduced the over-excitation of information flow in spontaneous brain activity and altered the signal spectrum of EEG rhythms.

摘要

背景

特级初榨橄榄油（EVOO）是一种具有高认知功能保护作用的天然化合物，可积极改变大脑动力学和内频和外频连接的混合。

目的

跨频耦合对同频耦合的平衡可以构建一个非线性指数（NI），该指数包含大脑区域之间信息流的过度兴奋以及实验时间的变化。本研究首次探讨了希腊高酚早收特级初榨橄榄油（HP-EH-EVOO）与中酚（MP-EVOO）和地中海饮食（MeDi）干预对轻度认知障碍（MCI）患者自发脑电图动态连通性的影响。

方法

43 名受试者（MeDi 组 14 名，MP-EVOO 组 16 名，HP-EH-EVOO 组 13 名）在治疗前后进行了脑电图静息状态记录（睁眼和闭眼）。根据我们的主导耦合模式模型，我们构建了一个动态综合动态功能连接图，该图列出了每对大脑区域的功能强度和主导耦合模式模型。

结果

在睁眼状态下，HP-EH-EVOO 组的 1-13 Hz 内信号谱和θ/β比值降低。干预改善了 FIDoCM 在各组和条件下，但在 HP-EH-EVOO 组更为明显（p<0.001）。最后，我们发现与 MP-EVOO 和 MeDi 组相比，HP-EH-EVOO 组在干预后 NI（ΔNITotal 和α）显著降低（p<0.0001）。