Laboratory of Biochemistry, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
1st Department of Neurology, "AHEPA" General Hospital Medical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece; Greek Association of Alzheimer's Disease and Related Disorders - GAADRD, Greece.
Exp Gerontol. 2021 Feb;144:111178. doi: 10.1016/j.exger.2020.111178. Epub 2020 Dec 5.
Even though Alzheimer's disease (AD) is the most common cause of dementia, the mechanisms governing the establishment and progression of the disease remain largely unknown. Here, we investigated the implication of the neuroprotective protein BMI1 (B lymphoma Mo-MLV insertion region 1 homolog) in AD and the possibility to reverse the onset of the disease through the administration of extra virgin olive oil (EVOO) in Mild Cognitive Impairment (MCI) patients. For this purpose, we utilized a wide bank of MCI patient samples to examine the potential effects of EVOO. We found that while EVOO treatment increases BMI1 levels, p53 levels drop in MCI patient serum after EVOO treatment for 12 months. Additionally, AD-related biomarkers (p-tau, Aβ1-42 and Aβ1-42/Aβ-40 ratio) return to normal levels after administration of EVOO in MCI patients for 12 months. Moreover, we show that upon EVOO administration, BMI1-upregulation correlates with reduction of oxidative stress and inflammatory responses. In conclusion, we provide clinical trial evidence to confirm that restoration of BMI1 activity through EVOO administration in MCI patients constitutes a potential therapeutic approach against neurodegeneration leading to AD.
尽管阿尔茨海默病（AD）是痴呆症最常见的病因，但控制疾病发生和进展的机制在很大程度上仍不清楚。在这里，我们研究了神经保护蛋白 BMI1（B 淋巴瘤 Mo-MLV 插入区 1 同源物）在 AD 中的作用，并探讨了通过在轻度认知障碍（MCI）患者中使用特级初榨橄榄油（EVOO）来逆转疾病发生的可能性。为此，我们利用大量 MCI 患者样本来研究 EVOO 的潜在作用。我们发现，虽然 EVOO 治疗可增加 BMI1 水平，但在 EVOO 治疗 12 个月后，MCI 患者血清中的 p53 水平下降。此外，在 MCI 患者中使用 EVOO 治疗 12 个月后，AD 相关生物标志物（p-tau、Aβ1-42 和 Aβ1-42/Aβ-40 比值）恢复正常水平。此外，我们还表明，在 EVOO 给药后，BMI1 的上调与氧化应激和炎症反应的减少相关。总之，我们提供了临床试验证据来证实，通过在 MCI 患者中使用 EVOO 来恢复 BMI1 的活性，可能是一种针对导致 AD 的神经退行性变的治疗方法。
