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保留中心凹内界膜剥除与完全内界膜剥除治疗近视性牵引性黄斑病变的效率比较。

Efficiency comparison with fovea-sparing internal limiting membrane peeling and complete internal limiting membrane peeling for treating myopic traction maculopathy.

机构信息

Department of Ophthalmology, Military Ophthalmological Center, General Hospital of Xinjiang Military Region, No. 754 Beijing Middle Road, Urumqi, 830054, Xinjiang, China.

出版信息

Graefes Arch Clin Exp Ophthalmol. 2022 Jan;260(1):73-81. doi: 10.1007/s00417-021-05320-y. Epub 2021 Jul 26.

Abstract

PURPOSE

To explore whether the efficacy of fovea-sparing internal limiting membrane peeling (FS-ILMP) is better than that of complete internal limiting membrane peeling (ILMP).

METHODS

This retrospective clinical study included 34 cases (34 eyes) with myopic traction maculopathy collected from June 2017 to February 2019. Twenty-three-gauge (23-G) pars plana vitrectomy (23G PPV) was performed on all patients. In the FS-ILMP group, 18 eyes retained the internal limiting membrane (ILM) of about 1 to 1.5 papillary diameter centered on fovea centralis, while in the standard ILMP group, the ILM was completely removed from 16 eyes. The best corrected visual acuity (BCVA), central foveal thickness (CFT), and other indexes were collected before and 6 months after surgery.

RESULTS

There was no significant difference in baseline clinical characteristics between the two groups. CFT and BCVA were significantly improved in both FS-ILMP and standard ILMP group, but the postoperative BCVA of the FS-ILMP group was significantly better than that of the standard ILMP group (P < 0.001). Two cases of subretinal effusion in macula were recorded in the FS-ILMP group, and three eyes in the standard ILMP group developed macular holes after surgery. Although both treatments relieved the mechanical traction of macular fovea, the patients in the FS-ILMP group showed better clinical outcomes in various aspects.

CONCLUSION

These results improved our understanding of the clinical application of vitrectomy combined with preservation of ILM upon the fovea centralis, which might lay a foundation for in-depth study on the treatment of myopic traction maculopathy.

摘要

目的

探讨保留中心凹的内界膜剥除术(FS-ILMP)与完全内界膜剥除术(ILMP)的疗效差异。

方法

本回顾性临床研究纳入了 2017 年 6 月至 2019 年 2 月期间收集的 34 例(34 只眼)近视牵拉性黄斑病变患者。所有患者均接受 23G 经睫状体平坦部玻璃体切除术(23G PPV)。在 FS-ILMP 组中,18 只眼保留了以黄斑中心凹为中心的约 1 至 1.5 个视乳头直径的内界膜(ILM),而在标准 ILMP 组中,16 只眼完全去除了 ILM。收集两组患者术前及术后 6 个月的最佳矫正视力(BCVA)、中心凹视网膜厚度(CFT)等指标。

结果

两组患者的基线临床特征无显著差异。FS-ILMP 组和标准 ILMP 组的 CFT 和 BCVA 均显著改善,但 FS-ILMP 组术后 BCVA 明显优于标准 ILMP 组(P < 0.001)。FS-ILMP 组有 2 例黄斑区视网膜下积液,标准 ILMP 组有 3 例术后发生黄斑裂孔。虽然两种治疗方法均缓解了黄斑中心凹的机械性牵拉,但 FS-ILMP 组患者在各方面均显示出更好的临床效果。

结论

这些结果加深了我们对玻璃体切割联合保留黄斑中心凹内界膜治疗近视牵拉性黄斑病变的临床应用的理解,为进一步研究近视牵拉性黄斑病变的治疗奠定了基础。

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