Mental Health Research Center, Rasoul Akram Medical Complex, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Department of Internal Medicine, School of Medicine, Hazrat-e Rasool General Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Clin Respir J. 2021 Nov;15(11):1168-1174. doi: 10.1111/crj.13423. Epub 2021 Aug 6.
Chronic obstructive pulmonary disease (COPD) increases susceptibility to sleep disturbances. This study aimed to evaluate the association between COPD severity criteria with sleep quality.
One hundred fifty-eight patients in Rasul Akram Hospital of Iran University of Medical Sciences, Tehran, Iran, from April 2019 to March 2021 diagnosed with COPD were examined using the Pittsburgh Sleep Quality Index (PSQI), COPD Assessment Test (CAT), modified Medical Research Council (mMRC) dyspnoea scale, spirometry and pulse oximetry.
Of 158 subjects, 125 patients were male (79%), and 33 were female (21%). The mean subject's age and FEV1/FVC ratio were 62.6 ± 11.5 and 65.6 ± 14.9%, respectively. The mean CAT scoring and Spo2 saturation reported 16.2 ± 7 and 91.5 ± 10.8%, respectively. The mean PSQI score was 8.2 ± 3.8. The association between PSQI score with FEV1 and FEV1/FVC ratio was not statistically significant (p = 0.64 and 0.58, respectively), whereas the association between PSQI scores with CAT score (p ˂ 0.0001, r = 0.51) and dyspnoea severity (p ˂ 0.0001, r = 0.29) were statistically significant. The patients with higher CAT score demonstrated poor sleep quality, particularly in longer sleep latency (p = 0.001, r = 0.056), bad subjective sleep quality (p ˂ 0.0001, r = 0.286), lower sleep efficiency (p = 0.002, r = 0.077), higher sleep disturbance (p ˂ 0.0001, r = 0.225), daytime dysfunction (p ˂ 0.0001, r = 0.259) and sleep medication intake times a week (p = 0.01, r = 0.069). Dyspnoea severity was attributed to bad subjective sleep quality (p ˂ 0.0001, r = 0.069), higher sleep disturbances (p = 0.005, r = 0.08), and daytime dysfunction (p ˂ 0.0001, r = 0.108).
The PSQI has a significant association with the CAT and mMRC for COPD patients and is linked to the disease's severity.
慢性阻塞性肺疾病（COPD）会增加睡眠障碍的易感性。本研究旨在评估 COPD 严重程度标准与睡眠质量之间的关系。
2019 年 4 月至 2021 年 3 月，来自伊朗德黑兰伊朗医科大学 Rasul Akram 医院的 158 名 COPD 患者接受了匹兹堡睡眠质量指数（PSQI）、COPD 评估测试（CAT）、改良医学研究委员会（mMRC）呼吸困难量表、肺功能和脉搏血氧饱和度检查。
158 名受试者中，125 名男性（79%），33 名女性（21%）。受试者的平均年龄和 FEV1/FVC 比值分别为 62.6±11.5 和 65.6±14.9%。CAT 评分和 Spo2 饱和度的平均值分别为 16.2±7 和 91.5±10.8%。PSQI 评分的平均值为 8.2±3.8。PSQI 评分与 FEV1 和 FEV1/FVC 比值之间的关联无统计学意义（p=0.64 和 0.58），而 PSQI 评分与 CAT 评分（p˂0.0001，r=0.51）和呼吸困难严重程度（p˂0.0001，r=0.29）之间的关联具有统计学意义。CAT 评分较高的患者睡眠质量较差，特别是在更长的睡眠潜伏期（p=0.001，r=0.056）、主观睡眠质量较差（p˂0.0001，r=0.286）、睡眠效率较低（p=0.002，r=0.077）、睡眠障碍更严重（p˂0.0001，r=0.225）、白天功能障碍（p˂0.0001，r=0.259）和每周睡眠药物摄入次数（p=0.01，r=0.069）。呼吸困难严重程度与主观睡眠质量差（p˂0.0001，r=0.069）、睡眠障碍更严重（p=0.005，r=0.08）和白天功能障碍（p˂0.0001，r=0.108）有关。
PSQI 与 COPD 患者的 CAT 和 mMRC 有显著关联，与疾病严重程度相关。
