Department of Ophthalmology (R.Y., A.H., M.U., M.K., K. Yuki, K. Tsubota), Keio University School of Medicine, Tokyo, Japan ; Epidemiology and Prevention Group (R.Y., N.S., A.H., T.S., T.Y., A.G., M. Inoue, M. Iwasaki, S.T.), Center for Public Health Sciences, National Cancer Center, Tokyo, Japan ; Center for Education and Educational Research (T.K.), Faculty of Education, Ehime University, Matsuyama, Japan ; Department of Public Health and Epidemiology (I.S.), Faculty of Medicine, Oita University, Oita, Japan ; Department of Public Health (K.A., S.M.), Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan ; Department of Hygiene and Preventive Medicine (K. Tanno, K.S.), School of Medicine, Iwate Medical University, Iwate, Japan ; Department of Public Health Medicine (K. Yamagishi, H.I.), Faculty of Medicine, and Health Services Research and Development Center, University of Tsukuba, Tsukuba, Japan ; Ibaraki Western Medical Center (Kazumasa Yamagishi), Chikusei, Japan ; Public Health (H.I.), Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Japan ; and Department of Public Health (N.Y.), Kochi University Medical School, Kochi, Japan.
Eye Contact Lens. 2021 Aug 1;47(8):449-455. doi: 10.1097/ICL.0000000000000814.
To investigate the relation between body mass index (BMI) and dry eye disease (DED).
We conducted a cross-sectional questionnaire-based survey in 85,264 Japanese men and women aged 40 to 74 years who participated in the Japan Public Health Center-based Prospective Study for the Next Generation (JPHC-NEXT Study). Dry eye disease was defined as the presence of severe symptoms or clinical diagnosis. A multivariable logistic regression model was used to estimate the odds ratios (ORs) of DED associated with BMI and their two-sided 95% confidence intervals (CIs). We adjusted for age, cohort area, visual display terminal time, smoking status, alcohol intake, education status, income status, as well as history of hormone replacement therapy for women.
Prevalence of DED was 23.4% (n = 19,985; 6,289 men, 13,696 women). Higher BMI was correlated with a lower prevalence of DED in a dose-response fashion, with an adjusted OR of DED (95% CI) per 1 kg/m2 increment of BMI of 0.98 (95% CI: 0.97-0.99) for men and 0.97 (95% CI: 0.97-0.98) for women.
This large population-based study showed an inverse relationship between BMI and prevalence of DED in a Japanese population. Underestimation of DED is warned, especially for participants with high BMI.
探讨体重指数（BMI）与干眼病（DED）之间的关系。
我们对 85264 名年龄在 40 至 74 岁的日本男女进行了一项基于横断面问卷调查的研究，这些参与者来自日本公共卫生中心前瞻性研究下一代（JPHC-NEXT 研究）。干眼病定义为存在严重症状或临床诊断。采用多变量逻辑回归模型来估计与 BMI 相关的 DED 的优势比（OR）及其双侧 95%置信区间（CI）。我们调整了年龄、队列区域、视觉显示终端时间、吸烟状况、饮酒状况、教育程度、收入状况以及女性激素替代疗法的病史。
DED 的患病率为 23.4%（n=19985；6289 名男性，13696 名女性）。BMI 越高，DED 的患病率呈剂量反应式下降，BMI 每增加 1kg/m2，男性 DED 的调整 OR（95%CI）为 0.98（95%CI：0.97-0.99），女性为 0.97（95%CI：0.97-0.98）。
这项基于大人群的研究表明，在日本人群中，BMI 与 DED 的患病率呈负相关。对于 BMI 较高的参与者，要警惕 DED 的低估。
