Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Ocul Surf. 2021 Jul;21:306-312. doi: 10.1016/j.jtos.2021.04.001. Epub 2021 Apr 18.
To investigate whether and how unhealthy sleep habits (i.e., the frequency of difficulty falling or staying asleep, and the frequency of waking up tired) and the duration of sleep are related to the prevalence of dry eye disease (DED) in a general population.
This study included a total of 106,282 subjects aged 40-74 years who participated in a baseline survey of the Japan Public Health Center-based Prospective Study for the Next Generation. DED was defined as the presence of clinically diagnosed DED or severe symptoms. Multivariable-adjusted logistic regression models were used to assess the relationships of various components of sleep status with DED.
Higher frequencies of having difficulty falling or staying asleep, and waking up tired were significantly related to increased DED in both sexes (P<0.001). Compared with those with 8 h/day of sleep, shorter sleepers had an increased prevalence of DED in both sexes, although DED was increased among men who slept ≥10 h/day. By comparing participants with the greatest vs. the least difficulty of falling asleep, the multivariable-adjusted odds ratios (95% confidence interval [CI]) were 2.23 (95% CI, 1.99-2.49) for men and 1.91 (95% CI, 1.76-2.07) for women. When analyzed separately, the magnitude of each relationship was stronger with severe DED symptoms than with clinically diagnosed DED.
Sleep deprivation and poor sleep quality were significantly related to DED in a Japanese population.
调查不健康的睡眠习惯（即入睡困难或保持睡眠的频率，以及醒来时感到疲倦的频率）和睡眠时间与普通人群中干眼症（DED）的患病率之间是否存在关联，以及如何关联。
本研究共纳入 106282 名年龄在 40-74 岁之间的受试者，他们参加了日本公共卫生中心前瞻性下一代研究的基线调查。DED 定义为存在临床诊断的 DED 或严重症状。采用多变量调整的逻辑回归模型评估睡眠状况各组成部分与 DED 的关系。
在男性和女性中，入睡困难或保持睡眠、醒来时感到疲倦的频率较高与 DED 的发生率增加显著相关（P<0.001）。与每天睡眠 8 小时的人相比，睡眠不足的人在两性中 DED 的患病率均增加，尽管每天睡眠时间≥10 小时的男性中 DED 增加。通过比较入睡最困难和最容易的参与者，多变量调整后的优势比（95%置信区间[CI]）分别为男性 2.23（95% CI，1.99-2.49）和女性 1.91（95% CI，1.76-2.07）。分别分析时，每种关系的严重程度与严重 DED 症状比与临床诊断的 DED 更为显著。
在日本人群中，睡眠剥夺和睡眠质量差与 DED 显著相关。
