• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Radical Annulation of 2-Cyanoaryl Acrylamides via C═C Double Bond Cleavage: Access to Amino-Substituted 2-Quinolones.

作者信息

Xia Wen-Jin, Fan Tai-Gang, Zhao Zhi-Wei, Chen Xin, Wang Xiang-Xiang, Li Ya-Min

机构信息

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, P. R. China.

出版信息

Org Lett. 2021 Aug 6;23(15):6158-6163. doi: 10.1021/acs.orglett.1c02281. Epub 2021 Jul 27.

DOI:10.1021/acs.orglett.1c02281
PMID:34313448
Abstract

A novel annulation of 2-cyanoaryl acrylamides via C═C double bond cleavage has been developed for facile and efficient access to a broad spectrum of functionalized 4-amino-2-quinolones, which are important -heterocycles. In this transformation, the solvent THF is demonstrated to play a crucial role, and the addition of alkyl radicals to nitrile, 1,5-hydride shift, and cleavage of the C-C bond are involved in the mechanism.

摘要

相似文献

1
Radical Annulation of 2-Cyanoaryl Acrylamides via C═C Double Bond Cleavage: Access to Amino-Substituted 2-Quinolones.
Org Lett. 2021 Aug 6;23(15):6158-6163. doi: 10.1021/acs.orglett.1c02281. Epub 2021 Jul 27.
2
Endorsing Organic Porous Polymers in Regioselective and Unusual Oxidative C═C Bond Cleavage of Styrenes into Aldehydes and Anaerobic Benzyl Alcohol Oxidation via Hydride Elimination.认可有机多孔聚合物在苯乙烯区域选择性且异常的氧化碳-碳键裂解生成醛以及通过氢化物消除实现厌氧苯甲醇氧化反应中的作用。
ACS Appl Mater Interfaces. 2021 Apr 7;13(13):15353-15365. doi: 10.1021/acsami.1c03158. Epub 2021 Mar 25.
3
Chemoselective Transformations of Amides: An Approach to Quinolones from β-Amido Ynones.酰胺的化学选择性转化：一种从β-酰胺基炔酮合成喹诺酮的方法。
Org Lett. 2023 Aug 11;25(31):5762-5767. doi: 10.1021/acs.orglett.3c01974. Epub 2023 Jul 27.
4
Rh-Catalyzed Annulation of Enaminones with Maleimides for Functionalized Aza-spiro α-Tetralones and Benzo[]isoindoles via C-H Activation/C═C Bond Cleavage.铑催化烯胺酮与马来酰亚胺通过C-H活化/C═C键断裂反应合成官能化氮杂螺α-四氢萘酮和苯并[]异吲哚。
Org Lett. 2024 Jan 12;26(1):142-147. doi: 10.1021/acs.orglett.3c03758. Epub 2023 Dec 18.
5
Direct Assembly of 4-Substituted Quinolines with Vinyl Azides as a Dual Synthon via C═C and C-N Bond Cleavage.通过 C═C 和 C-N 键断裂，将 4-取代喹啉与乙烯基叠氮化物直接组装成双合成子。
Org Lett. 2018 Aug 3;20(15):4434-4438. doi: 10.1021/acs.orglett.8b01718. Epub 2018 Jul 20.
6
Iodine-Mediated C═C Double Bond Cleavage toward Pyrido[2,1-]quinazolinones.碘介导的 C═C 双键断裂生成吡啶并[2,1-]喹唑啉酮。
Org Lett. 2022 May 6;24(17):3286-3290. doi: 10.1021/acs.orglett.2c01183. Epub 2022 Apr 21.
7
Applications of Radical Carbonylation and Amine Addition Chemistry: 1,4-Hydrogen Transfer of 1-Hydroxylallyl Radicals.自由基羰基化和胺加成化学的应用：1-羟基烯丙基自由基的1,4-氢转移
Acc Chem Res. 2018 Sep 18;51(9):2023-2035. doi: 10.1021/acs.accounts.8b00278. Epub 2018 Aug 23.
8
Cleavage of C-C Bonds for the Synthesis of C2-Substituted Quinolines and Indoles by Catalyst-Controlled Tandem Annulation of 2-Vinylanilines and Alkynoates.通过催化剂控制的 2-乙烯基苯胺和炔酸酯的串联环化反应合成 C2-取代的喹啉和吲哚的 C-C 键断裂。
Org Lett. 2018 Mar 16;20(6):1534-1537. doi: 10.1021/acs.orglett.8b00260. Epub 2018 Mar 8.
9
An access to 1,3-azasiline-fused quinolinones via oxidative heteroannulation involving silyl C(sp)-H functionalization.通过涉及硅基C(sp)-H官能化的氧化杂环化反应合成1,3-氮杂硅杂环戊烯并喹啉酮
Chem Commun (Camb). 2018 Feb 1;54(11):1367-1370. doi: 10.1039/c7cc08996a.
10
alpha-(Arylthio)imidoyl Radicals: [3 + 2] Radical Annulation of Aryl Isothiocyanates with 2-Cyano-Substituted Aryl Radicals.α-（芳硫基）亚氨基自由基：芳基异硫氰酸酯与2-氰基取代芳基自由基的[3 + 2]自由基环化反应
J Org Chem. 1997 Nov 28;62(24):8394-8399. doi: 10.1021/jo971128a.