Chen Wen-Shuai, Yang Fang, Wang Ting, Zhang Gang-Qiong, Wei Yi, Wang Mo-Han, Chen Zi-Sheng, Ji Kegong
College of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, China.
Org Lett. 2023 Aug 11;25(31):5762-5767. doi: 10.1021/acs.orglett.3c01974. Epub 2023 Jul 27.
An efficient and chemoselective transformation of β-amido ynones to 3-acyl-substituted quinolones and 3-H-quinolones has been developed. In this reaction, β-cyclic amido ynones can be selectively transformed into quinolones in anhydrous EG via a selective C═O bond cleavage, 1,5-O migration, and C═C bond recombination process. The practical approach of this reaction renders it a viable alternative for the construction of various quinolones.
已开发出一种将β-酰胺基炔酮高效且化学选择性地转化为3-酰基取代喹诺酮和3-H-喹诺酮的方法。在该反应中，β-环酰胺基炔酮可通过选择性的C═O键断裂、1,5-O迁移和C═C键重组过程，在无水乙二醇中选择性地转化为喹诺酮。该反应的实用方法使其成为构建各种喹诺酮的可行替代方法。
