动起来，甩掉它：有丝分裂后胞质分离可清除受损线粒体。

Move it to lose it: Mitocytosis expels damaged mitochondria.

机构信息

Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany.

Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany.

出版信息

Dev Cell. 2021 Jul 26;56(14):2014-2015. doi: 10.1016/j.devcel.2021.07.001.

DOI:10.1016/j.devcel.2021.07.001

PMID:34314697

Abstract

Mechanisms by which cells remove damaged mitochondria extracellularly are unclear. Recent work by Jiao and colleagues in Cell shows that migrating cells expel dysfunctional mitochondria in membrane-bound structures called migrasomes to maintain mitochondrial homeostasis.

摘要

细胞通过何种机制将损伤的线粒体从细胞外清除尚不清楚。焦�等人最近在《细胞》杂志上发表的工作表明，迁移细胞通过膜结合结构（称为迁移小体）将功能失调的线粒体排出，以维持线粒体的动态平衡。