Zhang Xide, Yao Liuhuan, Meng Yuanyuan, Li Bailong, Yang Yanyong, Gao Fu
Department of Radiation Medicine, Faculty of Naval Medicine, Naval Medical University, 200433, Shanghai, P. R. China.
Naval Medical University, Department of Traditional Chinese Medicine, Affiliated Hospital 1, 200433, Shanghai, P. R. China.
Cell Death Discov. 2023 Oct 18;9(1):381. doi: 10.1038/s41420-023-01673-x.
Migrasome is a novel cellular organelle produced during cell migration, and its biogenesis depends on the migration process. It is generated in a variety of cells such as immune cells, metastatic tumor cells, other special functional cells like podocytes and cells in developing organisms. It plays important roles in various fields especially in the information exchange between cells. The discovery of migrasome, as an important supplement to the extracellular vesicle system, provides new mechanisms and targets for comprehending various biological or pathological processes. In this article, we will review the discovery, structure, distribution, detection, biogenesis, and removal of migrasomes and mainly focus on summarizing its biological functions in cell-to-cell communication, homeostatic maintenance, embryonic development and multiple diseases. This review also creates prospects for the possible research directions and clinical applications of migrasomes in the future.
迁移体是细胞迁移过程中产生的一种新型细胞器，其生物发生依赖于迁移过程。它在多种细胞中产生，如免疫细胞、转移性肿瘤细胞、足细胞等其他特殊功能细胞以及发育生物体中的细胞。它在各个领域发挥着重要作用，尤其是在细胞间信息交换方面。迁移体的发现作为细胞外囊泡系统的重要补充，为理解各种生物学或病理学过程提供了新的机制和靶点。在本文中，我们将综述迁移体的发现、结构、分布、检测、生物发生和清除，并主要着重总结其在细胞间通讯、稳态维持、胚胎发育和多种疾病中的生物学功能。本综述还对迁移体未来可能的研究方向和临床应用进行了展望。
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