Tang Hua, Huang Zhe, Wang Ming, Luan Xingzhao, Deng Zengfu, Xu Jian, Fan Wei, He Dongsheng, Zhou Chong, Wang Liangbin, Li Jun, Zeng Fanfeng, Li Dongbo, Zhou Jie
Department of Neurosurgery, The People's Hospital of Jianyang City, Chengdu, China.
Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Front Cell Dev Biol. 2024 Aug 14;12:1420413. doi: 10.3389/fcell.2024.1420413. eCollection 2024.
Migrasomes are recently identified organelles that form at the ends or forks of retraction fibers (RFs) behind migrating cells and are expelled from the cell through cell migration. Migrasomes contain signaling molecules which are captured by surrounding cells along with migrasomes or released into the extracellular environment following the rupture of the migrasomes. Finally, through the action of these signaling molecules, migrasomes facilitate the entire process of information conveyance. In addition, migrasomes also serves as a "scavenger" by removing damaged mitochondria from the cell to ensure cellular viability. Thus, migrasomes play a pivotal role in the integration of temporal, spatial, specific chemical information and the clearance of cellular harmful substances, critical for grasping migrasomes' functions. This review delves into the latest advancements in migrasomes research, covering aspects such as migrasomes' discovery, distribution, structure and characteristics, genesis and regulation mechanisms, and their correlation with diseases. Additionally, we scrutinize the present investigational findings on migrasomes within the cancer domain, examining their potential impact on cancer and prospective research avenues.
迁移小体是最近发现的细胞器，在迁移细胞后方的收缩纤维（RFs）末端或分叉处形成，并通过细胞迁移从细胞中排出。迁移小体含有信号分子，这些信号分子会与迁移小体一起被周围细胞捕获，或者在迁移小体破裂后释放到细胞外环境中。最后，通过这些信号分子的作用，迁移小体促进了整个信息传递过程。此外，迁移小体还通过清除细胞内受损的线粒体，充当“清道夫”，以确保细胞的活力。因此，迁移小体在整合时间、空间、特定化学信息以及清除细胞有害物质方面发挥着关键作用，这对于理解迁移小体的功能至关重要。本综述深入探讨了迁移小体研究的最新进展，涵盖迁移小体的发现、分布、结构和特征、形成和调控机制以及它们与疾病的相关性等方面。此外，我们审视了目前在癌症领域关于迁移小体的研究结果，探讨它们对癌症的潜在影响以及未来的研究方向。
