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兔血小板中[3H] - 丙咪嗪结合的最大结合量（Bmax）的昼夜节律。

Circadian rhythm of the Bmax of [3H]-imipramine binding in rabbit platelets.

作者信息

Galzin A M, Langer S Z

机构信息

Department of Biology, Laboratoires d'Etudes et de Recherches Synthélabo, Paris, France.

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1987 Oct;336(4):464-6. doi: 10.1007/BF00164884.

DOI:10.1007/BF00164884
PMID:3431599
Abstract

[3H]-imipramine binding was measured in rabbit blood platelet membranes on a 24 h cycle. Animals were kept on a 14 h light (L) 10 h dark (D) schedule, and blood samples were collected at L + 2, L + 8, D + 2, D + 8 and L + 2 h on a following cycle. Significant differences were found for Bmax values of [3H]-imipramine binding, with highest values during the dark phase and lowest during the light phase. No significant differences were found in Kd values. These results suggest the existence of a circadian rhythm for the Bmax of [3H]-imipramine binding in blood platelets.

摘要

在兔血小板膜上以24小时周期测量[³H] - 丙咪嗪结合。动物维持14小时光照（L）、10小时黑暗（D）的时间表，并在下一个周期的L + 2、L + 8、D + 2、D + 8和L + 2小时采集血样。发现[³H] - 丙咪嗪结合的Bmax值存在显著差异，黑暗期最高，光照期最低。Kd值未发现显著差异。这些结果表明血小板中[³H] - 丙咪嗪结合的Bmax存在昼夜节律。

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Naunyn Schmiedebergs Arch Pharmacol. 1987 Oct;336(4):464-6. doi: 10.1007/BF00164884.
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引用本文的文献

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Studies on the serotonin transporter in platelets.
Experientia. 1988 Feb 15;44(2):127-30. doi: 10.1007/BF01952194.
2
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Naunyn Schmiedebergs Arch Pharmacol. 1989 Jul;340(1):41-4. doi: 10.1007/BF00169205.

本文引用的文献

1
Long-term effect of lithium on the uptake of 5-hydroxytryptamine by human platelets.锂对人血小板摄取5-羟色胺的长期影响。
Br J Clin Pharmacol. 1980 Apr;9(4):321-5. doi: 10.1111/j.1365-2125.1980.tb01057.x.
2
Circadian rhythm of [3H]imipramine binding in the rat suprachiasmatic nuclei.大鼠视交叉上核中[3H]丙咪嗪结合的昼夜节律。
Eur J Pharmacol. 1983 Feb 18;87(2-3):331-3. doi: 10.1016/0014-2999(83)90348-5.
3
Circadian rhythm of serotonin uptake in the blood platelets of normal controls.
Biol Psychiatry. 1984 Nov;19(11):1579-84.
4
Tryptamine, a substrate for the serotonin transporter in human platelets, modifies the dissociation kinetics of [3H]imipramine binding: possible allosteric interaction.色胺是人类血小板中血清素转运体的一种底物，它会改变[3H]丙咪嗪结合的解离动力学：可能存在变构相互作用。
J Neurochem. 1985 Feb;44(2):349-56. doi: 10.1111/j.1471-4159.1985.tb05423.x.
5
Antidepressant-binding sites in brain and platelets.大脑和血小板中的抗抑郁药结合位点。
Ciba Found Symp. 1986;123:3-29. doi: 10.1002/9780470513361.ch2.
6
Inhibition of 3H-imipramine binding by plasma from depressed and normal subjects.抑郁症患者和正常受试者血浆对3H-丙咪嗪结合的抑制作用。
Psychiatry Res. 1986 Apr;17(4):261-7. doi: 10.1016/0165-1781(86)90073-9.
7
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Biochim Biophys Acta. 1987 Jan 20;923(1):8-21. doi: 10.1016/0304-4165(87)90119-x.
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J Neurochem. 1987 Feb;48(2):560-5. doi: 10.1111/j.1471-4159.1987.tb04129.x.
9
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Psychopharmacology (Berl). 1986;89(4):456-61. doi: 10.1007/BF02412121.
10
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Psychopharmacology (Berl). 1986;88(4):493-5. doi: 10.1007/BF00178513.