Modai I, Malmgren R, Asberg M, Beving H
Psychopharmacology (Berl). 1986;88(4):493-5. doi: 10.1007/BF00178513.
The circadian rhythm of serotonin active transport in human platelets was investigated in ten healthy men, aged 27-35 years. Blood was collected at 08.00, 14.00, 20.00, 02.00 and 08.00 hours the next morning. Simultaneous evaluation of the mean platelet volume, platelet distribution width, platelet distribution skewness and platelet number in whole blood was performed. Km and Vmax for serotonin transport varied considerably among individuals over 24 h. However, the mean values and distribution of these kinetic parameters were reduced at 02.00 hours. All platelet size or number parameters were stable and normal over 24 h; therefore, the reduction in mean Km and Vmax values at 02.00 h is not related to morphological platelet differences but either to platelet intrinsic factors or plasmatic variables. Knowledge of the affinity and capacity of serotonin transport throughout the diurnal cycle is important for future comparisons with depressed patients as well as other hormonal rhythms in patients and healthy humans.
对10名年龄在27至35岁之间的健康男性的人体血小板中血清素主动转运的昼夜节律进行了研究。在上午8点、下午2点、晚上8点、凌晨2点以及第二天上午8点采集血液。同时对全血中的平均血小板体积、血小板分布宽度、血小板分布偏度和血小板数量进行评估。血清素转运的Km和Vmax在24小时内个体间差异很大。然而，这些动力学参数的平均值和分布在凌晨2点时降低。所有血小板大小或数量参数在24小时内保持稳定且正常；因此，凌晨2点时平均Km和Vmax值的降低与血小板形态差异无关，而是与血小板内在因素或血浆变量有关。了解血清素转运在昼夜周期中的亲和力和容量，对于未来与抑郁症患者以及患者和健康人体内的其他激素节律进行比较非常重要。
