Soriano María José, Botella Inmaculada Molina, Sadeghi Sara, Rios Andrea Palomar, Balasch Sebastià, Luján Saturnino, Pellicer Nuria, Rubio José María
Grupo Acreditado en Investigación en Medicina Reproductiva, Instituto de Investigación Sanitaria La Fe (IISLaFe), Valencia, Spain.
Fundación IVI, Instituto de Investigación Sanitaria La Fe (IISLaFe), Valencia, Spain.
J Hum Reprod Sci. 2021 Apr-Jun;14(2):162-166. doi: 10.4103/jhrs.JHRS_128_18. Epub 2021 Jun 28.
Some vaginal lubricants and ultrasound gels are known to be detrimental to sperm function and therefore could negatively affect fertility.
The aim of the current study was to develop a sperm motility index (SMI) to test the sperm toxicity of ultrasound gels and vaginal lubricants used in reproductive medicine.
Two ultrasound gels (Aquasonic and Kefus) and five vaginal lubricants (Vaginesil™, Velastisa, K-Y Jelly, Control, and Durex) were studied. Three different concentrations (1%, 5%, and 10%) of each lubricant were tested.
SMI was calculated dividing the percentage of progressively motile sperm in each tested gel by that in the control at 0.5, 1, 2, and 24 h of incubation at 5% of CO and 37°C. SMI values <0.75 indicate sperm toxicity.
The main outcome measured was SMI for each concentration and time of incubation.
Only Durex did not show any deleterious effect on sperm quality. The rest of lubricants presented different degrees of toxicity. Vaginesil™ resulted in toxic for all concentrations and incubation periods (SMI < 0.12). Control and Velastisa presented toxicity at 10% after 2 h, while K-Y Jelly showed toxicity at 10% from 1 h of incubation. Regarding ultrasound gels, Aquasonic showed toxic effects after only 0.5 h (SMI = 0.70 ± 0.15), while Kefus showed slightly toxic effects after 2 h (SMI 0.69 ± 0.07).
SMI is an accurate tool to evaluate sperm toxicity. One of the main strengths of the article is the inclusion of representative semen samples and known products used worldwide. This study has a relevant clinical translation since it highlights the importance of evaluating the possible sperm toxicity of simple products used in reproductive medicine.
已知一些阴道润滑剂和超声凝胶对精子功能有害，因此可能会对生育能力产生负面影响。
本研究的目的是开发一种精子活力指数（SMI），以测试生殖医学中使用的超声凝胶和阴道润滑剂的精子毒性。
研究了两种超声凝胶（Aquasonic和Kefus）和五种阴道润滑剂（Vaginesil™、Velastisa、K-Y Jelly、对照和杜蕾斯）。测试了每种润滑剂的三种不同浓度（1%、5%和10%）。
在5%二氧化碳和37°C孵育0.5、1、2和24小时时，通过将每个测试凝胶中进行性运动精子的百分比除以对照中的百分比来计算SMI。SMI值<0.75表明存在精子毒性。
测量的主要结果是每种浓度和孵育时间的SMI。
只有杜蕾斯对精子质量没有显示出任何有害影响。其余润滑剂呈现出不同程度的毒性。Vaginesil™在所有浓度和孵育期均表现出毒性（SMI<0.12）。对照和Velastisa在2小时后10%浓度时呈现毒性，而K-Y Jelly在孵育1小时后10%浓度时显示出毒性。关于超声凝胶，Aquasonic仅在0.5小时后显示出毒性作用（SMI = 0.70±0.15），而Kefus在2小时后显示出轻微毒性作用（SMI 0.69±0.07）。
SMI是评估精子毒性的准确工具。本文的主要优点之一是纳入了具有代表性的精液样本和全球使用的知名产品。这项研究具有相关的临床意义，因为它强调了评估生殖医学中使用的简单产品可能的精子毒性的重要性。
