Kutteh W H, Chao C H, Ritter J O, Byrd W
University of Texas Southwestern Medical Center at Dallas, Department of Obstetrics and Gynecology, USA.
Int J Fertil Menopausal Stud. 1996 Jul-Aug;41(4):400-4.
To determine the effects of natural vegetable oils and vaginal lubricants on sperm motion and viability.
Four widely used vaginal lubricants (K-Y Jelly, Astroglide, Replens, and Touch) and two vegetable oil products that have been used as vaginal lubricants were purchased through local vendors. Sperm was obtained by masturbation without lubrication from normal, healthy donors. Lubricants were mixed with sperm from individual donors and the effects on sperm motility were determined at 1, 15, 30, and 60 minutes.
Southwestern Fertility Associates of The University of Texas Southwestern Medical Center at Dallas.
Sperm motility was evaluated by manual motility counts and by computer-assisted semen analysis. Sperm viability was evaluated with Hoechst 33258 dye. The effects of the various lubricants were compared with those of a spermicidal agent, Gynol II (negative control) and Ham's F-10 (positive control).
Commercial lubricants inhibited sperm motility by 60-100% after 60 minutes of incubation. Sperm exposed to Replens or Astroglide were nonmotile and nonviable after incubation for 60 minutes, similar to the control, nonoxynol-9 containing product Gynol II. Canola oil had no detrimental effects and was indistinguishable from Ham's F-10 in terms of sperm viability and motility.
For couples with infertility, the use of vaginal lubricants during intercourse is not recommended. In cases where a lubricant is required, careful selection can maximize sperm motility and viability.
确定天然植物油和阴道润滑剂对精子运动及活力的影响。
通过当地供应商购买了四种广泛使用的阴道润滑剂（K-Y凝胶、爱丝滑、Replens和Touch）以及两种曾用作阴道润滑剂的植物油产品。从正常、健康的供体处通过无润滑手淫获取精子。将润滑剂与来自各个供体的精子混合，并在1分钟、15分钟、30分钟和60分钟时测定对精子活力的影响。
达拉斯德克萨斯大学西南医学中心的西南生育协会。
通过手动活力计数和计算机辅助精液分析评估精子活力。用Hoechst 33258染料评估精子活力。将各种润滑剂的效果与一种杀精剂Gynol II（阴性对照）和Ham's F-10（阳性对照）的效果进行比较。
孵育60分钟后，市售润滑剂使精子活力降低60%-100%。孵育60分钟后，接触Replens或爱丝滑的精子无活力且无活性，类似于含壬苯醇醚-9的对照产品Gynol II。菜籽油没有不利影响，在精子活力和运动方面与Ham's F-10无差异。
对于不育夫妇，不建议在性交期间使用阴道润滑剂。在需要使用润滑剂的情况下，谨慎选择可使精子活力和活性最大化。
