Faculty of Medicine and Healthcare Sciences, Nottingham University Hospital, Nottingham, UK.
NUH Life Fertility Services, Nottingham University Hospital, Nottingham, UK.
Hum Fertil (Camb). 2023 Dec;26(5):1028-1031. doi: 10.1080/14647273.2022.2053214. Epub 2022 Apr 4.
Couples trying to conceive or providing samples for Assisted Reproductive Technologies (ART) are advised against the use of lubricant-gels due to the risk of sperm-toxicity. However, gels now exist which are specifically formulated to help couples conceive but without consensus on their toxicity relative to non-specialist products. This study tested gels recently introduced as 'sperm friendly' (FertilSafe Plus, Fertile Check) alongside established lubricants intended for pleasure only using a recently published toxicity testing regime. Computer Assisted Sperm Analysis (CASA) was performed at 1 and 2 h on donor sperm ( = 12) pre-incubated with each gel (10% v/v) and controls. All gels led to a significant loss of motility/velocity at 1 and 2 h ( < 0.01), with the most significant loss from the 2 Durex pleasure products (11% and 15%, vs 47% progression) at 60 min, although these performed better than saliva (used as negative control). Incubation with FertilSafePlus led to the smallest loss of motility (24% vs 47%) at 1 h. Saliva and products designed for lubrication only exhibited the most negative effect on motility and those marketed as 'sperm safe' could be considered the best performers. Whether these affects are due to direct toxicity or are indirect due to other factors such as viscosity, pH or osmolality remains uncertain.
建议尝试怀孕或为辅助生殖技术 (ART) 提供样本的夫妇避免使用润滑剂凝胶，因为它们存在精子毒性风险。然而，现在已经有专门为帮助夫妇怀孕而设计的凝胶，但它们的毒性相对于非专业产品的毒性还没有共识。本研究使用最近公布的毒性测试方案，测试了最近推出的被称为“精子友好型”的凝胶（FertilSafe Plus、Fertile Check）以及仅用于愉悦的既定润滑剂。在与每个凝胶（10%v/v）和对照物预孵育 1 和 2 小时后，对供体精子（ = 12）进行计算机辅助精子分析 (CASA)。所有凝胶在 1 和 2 小时时均导致明显的运动/速度丧失（ < 0.01），其中最显著的丧失来自 2 个 Durex 愉悦产品（11%和 15%，与 60 分钟时的 47%进展相比），尽管它们的性能优于唾液（用作阴性对照）。在 1 小时时，FertilSafePlus 孵育导致运动能力下降最小（24%对 47%）。仅用于润滑的唾液和产品对运动能力的影响最为负面，而那些被标记为“精子安全”的产品则可以被认为是性能最好的产品。这些影响是由于直接毒性还是由于其他因素（如粘度、pH 值或渗透压）间接引起的，目前尚不确定。
