Prato A, Scapagnini U, Rapisarda E, Giuffrida R, Palmeri A, Caruso A, Clementi G
Department of Pharmacology, University of Catania Medical School, Italy.
Neurosci Lett. 1987 Oct 29;81(3):303-8. doi: 10.1016/0304-3940(87)90400-9.
Intracerebroventricular (i.c.v.) injection of (Asul,7)eel-calcitonin, a synthetic analogue of eel-calcitonin, at doses of 3 or 6 IU/rat, (but not at 1.5 IU/rat) determined analgesic activity, in male rats, as evaluated by the 'hot-plate' test. Also electrophysiological studies carried out on 13 neurons belonging to the nucleus raphe magnus (NRM) showed that i.c.v. administration of the same doses of (Asul,7)eel-calcitonin increased the spontaneous cellular firing rate. No modification of the discharge frequency was observed when 1.5 IU/rat (Asul,7)eel-calcitonin was used. Authors suggest that the analgesic activity induced by i.c.v. injection of (Asul,7)eel-calcitonin is due, at least in part, to mechanisms affecting NRM neurons.
通过“热板”试验评估，向雄性大鼠脑室内（i.c.v.）注射剂量为3或6国际单位/大鼠（而非1.5国际单位/大鼠）的（Asul,7）鳗降钙素（鳗鱼降钙素的一种合成类似物）可产生镇痛活性。此外，对13个中缝大核（NRM）神经元进行的电生理研究表明，脑室内注射相同剂量的（Asul,7）鳗降钙素可提高细胞自发放电率。当使用1.5国际单位/大鼠的（Asul,7）鳗降钙素时，未观察到放电频率的改变。作者认为，脑室内注射（Asul,7）鳗降钙素所诱导的镇痛活性至少部分归因于影响NRM神经元的机制。
