Guidobono F, Netti C, Sibilia V, Olgiati V R, Pecile A
Pharmacology. 1985;31(6):342-8. doi: 10.1159/000138143.
The possibility that the catecholaminergic (CA) system might be involved in calcitonin (CT)-induced analgesia was examined. The administration of the neurotoxin for CA neurons, 6-hydroxydopamine (6-OHDA) significantly reduced salmon CT (sCT) analgesia as measured in rats by the hot-plate test. Pretreatment with an alpha- and beta-blocker (phentolamine and propranolol) was also effective in lowering significantly the activity of sCT. When the two drugs were administered alone, propranolol, but not phentolamine, reduced the analgesic effect of sCT. A more pronounced and long-lasting inhibitory effect on sCT-analgesia was obtained using atenolol (selective beta 1-receptor blocker). The present data support the role of the CA system in sCT-induced analgesic activity.
研究了儿茶酚胺能（CA）系统可能参与降钙素（CT）诱导镇痛的可能性。给CA神经元注射神经毒素6-羟基多巴胺（6-OHDA），通过热板试验在大鼠中测量发现，这显著降低了鲑鱼降钙素（sCT）的镇痛效果。用α和β阻滞剂（酚妥拉明和普萘洛尔）预处理也能有效显著降低sCT的活性。当单独给予这两种药物时，普萘洛尔而非酚妥拉明降低了sCT的镇痛效果。使用阿替洛尔（选择性β1受体阻滞剂）对sCT镇痛有更明显且持久的抑制作用。目前的数据支持CA系统在sCT诱导的镇痛活性中的作用。
