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Downregulation of the Long Noncoding RNA IALNCR Targeting MAPK8/JNK1 Promotes Apoptosis and Antagonizes Bovine Viral Diarrhea Virus Replication in Host Cells.长链非编码 RNA IALNCR 下调靶向 MAPK8/JNK1 促进宿主细胞凋亡并拮抗牛病毒性腹泻病毒复制。
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本文引用的文献

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Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection.非肺炎型 SARS-CoV-2 感染早期病毒控制中的保护性免疫轨迹。
Nat Commun. 2022 Feb 23;13(1):1018. doi: 10.1038/s41467-022-28508-0.
2
Long Noncoding RNA IFITM4P Regulates Host Antiviral Responses by Acting as a Competing Endogenous RNA.长链非编码 RNA IFITM4P 通过作为竞争性内源性 RNA 调节宿主抗病毒反应。
J Virol. 2021 Oct 13;95(21):e0027721. doi: 10.1128/JVI.00277-21. Epub 2021 Jul 21.
3
Interferon-Induced Transmembrane Protein 3 Blocks Fusion of Diverse Enveloped Viruses by Altering Mechanical Properties of Cell Membranes.干扰素诱导跨膜蛋白 3 通过改变细胞膜的机械特性来阻止多种包膜病毒的融合。
ACS Nano. 2021 May 25;15(5):8155-8170. doi: 10.1021/acsnano.0c10567. Epub 2021 Mar 3.
4
miR-24 Targets the Transmembrane Glycoprotein Neuropilin-1 in Human Brain Microvascular Endothelial Cells.微小RNA-24靶向人脑血管内皮细胞中的跨膜糖蛋白神经纤毛蛋白-1
Noncoding RNA. 2021 Feb 2;7(1):9. doi: 10.3390/ncrna7010009.
5
CD225 Proteins: A Family Portrait of Fusion Regulators.CD225 蛋白：融合调控因子的全家福。
Trends Genet. 2021 May;37(5):406-410. doi: 10.1016/j.tig.2021.01.004. Epub 2021 Jan 29.
6
Malignancy and IFITM3: Friend or Foe?恶性肿瘤与IFITM3：敌还是友？
Front Oncol. 2020 Dec 8;10:593245. doi: 10.3389/fonc.2020.593245. eCollection 2020.
7
Homology-guided identification of a conserved motif linking the antiviral functions of IFITM3 to its oligomeric state.同源性指导鉴定一个保守基序，将 IFITM3 的抗病毒功能与其寡聚状态联系起来。
Elife. 2020 Oct 28;9:e58537. doi: 10.7554/eLife.58537.
8
Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity.神经纤毛蛋白-1 促进 SARS-CoV-2 细胞进入和感染性。
Science. 2020 Nov 13;370(6518):856-860. doi: 10.1126/science.abd2985. Epub 2020 Oct 20.
9
miR-24-3p promotes colon cancer progression by targeting ING1.微小RNA-24-3p通过靶向ING1促进结肠癌进展。
Signal Transduct Target Ther. 2020 Aug 25;5(1):171. doi: 10.1038/s41392-020-0206-y.
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Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes.白藜芦醇三聚体通过降低内体中的抗病毒限制来增强向造血干细胞的基因传递。
Blood. 2019 Oct 17;134(16):1298-1311. doi: 10.1182/blood.2019000040.

IFITM 假基因编码的长非编码 RNA 的间接抗病毒潜力。

The Indirect Antiviral Potential of Long Noncoding RNAs Encoded by IFITM Pseudogenes.

机构信息

HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA.

出版信息

J Virol. 2021 Oct 13;95(21):e0068021. doi: 10.1128/JVI.00680-21. Epub 2021 Jul 28.

DOI:10.1128/JVI.00680-21
PMID:34319781
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8513482/
Abstract

The interferon-induced transmembrane () gene family performs multiple functions in immunity, including inhibition of virus entry into cells. The repertoire varies widely between species and consists of protein-coding genes and pseudogenes. The selective forces driving pseudogenization within gene families are rarely understood. In this issue, the human pseudogene is characterized as a virus-induced, long noncoding RNA that contributes to restriction of influenza A virus by regulating mRNA levels of , , and .

摘要

干扰素诱导跨膜（）基因家族在免疫中发挥多种功能，包括抑制病毒进入细胞。该基因家族在物种间的多样性很大，由蛋白编码基因和假基因组成。驱动基因家族中假基因化的选择压力很少被理解。在本期中，人类假基因被描述为一种病毒诱导的长非编码 RNA，通过调节、和的 mRNA 水平来限制甲型流感病毒。