IFITM 假基因编码的长非编码 RNA 的间接抗病毒潜力。
The Indirect Antiviral Potential of Long Noncoding RNAs Encoded by IFITM Pseudogenes.
机构信息
HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA.
出版信息
J Virol. 2021 Oct 13;95(21):e0068021. doi: 10.1128/JVI.00680-21. Epub 2021 Jul 28.
Abstract
The interferon-induced transmembrane () gene family performs multiple functions in immunity, including inhibition of virus entry into cells. The repertoire varies widely between species and consists of protein-coding genes and pseudogenes. The selective forces driving pseudogenization within gene families are rarely understood. In this issue, the human pseudogene is characterized as a virus-induced, long noncoding RNA that contributes to restriction of influenza A virus by regulating mRNA levels of , , and .
摘要
干扰素诱导跨膜（）基因家族在免疫中发挥多种功能，包括抑制病毒进入细胞。该基因家族在物种间的多样性很大，由蛋白编码基因和假基因组成。驱动基因家族中假基因化的选择压力很少被理解。在本期中，人类假基因被描述为一种病毒诱导的长非编码 RNA，通过调节、和的 mRNA 水平来限制甲型流感病毒。
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