18F-FDG PET/CT 和 68Ga-FAPI-4 PET/CT 对眼黑色素瘤患者双侧膝关节骨关节炎的表现

18F-FDG PET/CT and 68Ga-FAPI-4 PET/CT Findings of Bilateral Knee Osteoarthritis in a Patient With Uveal Malignant Melanoma.

机构信息

From the Clinic of Nuclear Medicine, Istanbul Training and Research Hospital, Istanbul, Turkey.

出版信息

Clin Nucl Med. 2022 Feb 1;47(2):e144-e146. doi: 10.1097/RLU.0000000000003854.

PMID:34319962

Abstract

We present the findings of 68Ga-FAPI-4 PET/CT and 18F-FDG PET/CT of a metastatic malignant melanoma patient with osteoarthritis. A 65-year-old woman with a history of metastatic uveal malignant melanoma was referred to 18F-FDG PET/CT for restaging after enucleation and chemotherapy. 18F-FDG PET/CT imaging showed high radiotracer uptake in liver metastases; additionally mild uptake due to osteoarthritis was observed in both knees. However, although 68Ga-FAPI-4 showed lower uptake in liver lesions, it showed a more prominent uptake in both knee joints compared with 18F-FDG.

摘要

我们报告了一位患有骨关节炎的转移性恶性黑色素瘤患者的 68Ga-FAPI-4 PET/CT 和 18F-FDG PET/CT 检查结果。一位 65 岁女性，患有转移性眼葡萄膜恶性黑色素瘤，在眼球摘除和化疗后进行 18F-FDG PET/CT 分期检查。18F-FDG PET/CT 成像显示肝转移灶有高放射性示踪剂摄取；此外，双膝还观察到因骨关节炎引起的轻度摄取。然而，尽管 68Ga-FAPI-4 在肝病变部位的摄取较低，但与 18F-FDG 相比，在两个膝关节的摄取更为明显。