肺结核治疗中断的流行情况及其相关因素。

Prevalence and associated factors of tuberculosis treatment abandonment.

机构信息

Universidade Estadual do Ceará, Programa de Pós-graduação Cuidados Clínicos em Enfermagem e Saúde, Fortaleza, CE, Brasil.

Universidade Estadual do Piauí, Curso de Enfermagem, Parnaíba, PI, Brasil.

出版信息

Rev Esc Enferm USP. 2021 Jul 23;55:e03767. doi: 10.1590/S1980-220X2020039203767. eCollection 2021.

DOI:10.1590/S1980-220X2020039203767

PMID:34320115

Abstract

OBJECTIVE

To estimate the prevalence of tuberculosis treatment abandonment and its associated factors.

METHOD

Cross-sectional study which used cases of tuberculosis in the System of Information on Notification Aggravations (Sistema de Informação de Agravos de Notificação) from 2001 to 2017 in Ceará state. This study included 74,006 cases and the outcome was the closing situation "treatment abandonment". A multivariate analysis was performed to estimate the association between the variables with abandonment.

RESULTS

Throughout the period, the abandonment rate was 12.54%. A higher abandonment prevalence was verified among people who live in the urban zone (PR = 2.45; 95%CI: 2.20-2.74), who are readmitted after abandonment (PR = 2.84; 95%CI: 2.68-3.01), among those notified as recurrent (PR = 1.22; 95%CI: 1.10-1.35) and among drinkers (PR = 1.50; 95%CI: 1.42-1.58). Those who were sputum smear-positive (PR = 1.11; 95%CI: 1.03-1.19) or for whom sputum smear was unperformed (PR = 1.30; 95%CI: 1.20-1.40), coinfection (PR = 2.04; CI95%: 1.89-2.21) and who were not submitted to serology (PR = 1.62; 95%CI: 1.53-1.71) have also a higher prevalence of tuberculosis treatment abandonment.

CONCLUSION

Tuberculosis treatment abandonment is associated to biological and social factors, habits, and health service structure.

摘要

目的

评估结核病治疗中断的流行率及其相关因素。

方法

本研究为 2001 年至 2017 年期间在塞阿拉州利用 Notification Aggravations 信息系统（Sistema de Informação de Agravos de Notificação）中结核病病例进行的横断面研究。本研究共纳入了 74006 例病例，结局变量为“治疗中断”的结案情况。采用多变量分析来评估与中断相关的变量之间的关联。

结果

在整个研究期间，治疗中断率为 12.54%。在以下人群中，治疗中断的流行率更高：居住在城市地区的人群（PR = 2.45；95%CI：2.20-2.74）、中断后重新入院的人群（PR = 2.84；95%CI：2.68-3.01）、复发报告的人群（PR = 1.22；95%CI：1.10-1.35）和饮酒者（PR = 1.50；95%CI：1.42-1.58）。痰涂片阳性（PR = 1.11；95%CI：1.03-1.19）或未进行痰涂片检查（PR = 1.30；95%CI：1.20-1.40）、合并感染（PR = 2.04；95%CI：1.89-2.21）和未进行血清学检查的患者（PR = 1.62；95%CI：1.53-1.71）也具有更高的结核病治疗中断发生率。