Health Sciences Graduation Program, Health Sciences Center, State University of Londrina, Londrina, Paraná, Brazil.
Health Sciences Graduation Program, Health Sciences Center, State University of Londrina, Londrina, Paraná, Brazil; Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Department of Psychiatry, Medical University of Plovdiv and Technological Center for Emergency Medicine, Plovdiv, Bulgaria; IMPACT Strategic Research Centre, Deakin University, Geelong, Vic, Australia.
J Affect Disord. 2021 Nov 1;294:410-419. doi: 10.1016/j.jad.2021.07.057. Epub 2021 Jul 18.
There is a strong comorbidity between mood disorders and metabolic syndrome (MetS). Increased levels of reactive oxygen and nitrogen species (RONS) and nitro-oxidative stress toxicity (NOSTOX) partially underpin this comorbidity.
To examine the associations of RONS/NOSTOX biomarkers with MetS after adjusting for the significant effects of mood disorders (major depression, and bipolar type 1 and 2), generalized anxiety disorder (GAD), tobacco use disorder (TUD), and male sex.
The study included subjects with (n=65) and without (n=107) MetS and measured levels of superoxide dismutase 1 (SOD1), lipid hydroperoxides (LOOH), nitric oxide metabolites (NOx), malondialdehyde (MDA), and advanced oxidation protein products (AOPP) and computed z unit-weighted composite scores which reflect RONS/NOSTOX. The study included 105 patients with mood disorders, 46 with GAD, and 95 with TUD.
MetS was associated with increased levels of MDA and AOPP, independently from mood disorders, TUD, sex and GAD. Atherogenicity and insulin resistance (IR) were significantly associated with a NOSTOX composite score. Mood disorders, TUD, GAD, male sex and MetS independently contribute to increased RONS/NOSTOX. The RONS/NOSTOX profile of MetS was different from that of GAD, which showed increased SOD1 and NOx levels. TUD was accompanied by increased SOD1, LOOH and MDA, and male sex by increased LOOH and AOPP.
MetS is characterized by increased lipid peroxidation with aldehyde formation and chlorinative stress, and atherogenicity and IR are strongly mediated by RONS/NOSTOX. Partially shared RONS/NOSTOX pathways underpin the comorbidity of MetS with mood disorders, GAD, and TUD.
情绪障碍和代谢综合征（MetS）之间存在很强的共病关系。活性氧和氮物种（RONS）和硝基氧化应激毒性（NOSTOX）水平升高部分解释了这种共病关系。
在调整情绪障碍（重度抑郁症、1 型和 2 型双相情感障碍）、广泛性焦虑障碍（GAD）、烟草使用障碍（TUD）和男性的显著影响后，检查 RONS/NOSTOX 生物标志物与 MetS 的相关性。
该研究纳入了 MetS 患者（n=65）和非 MetS 患者（n=107），并测量了超氧化物歧化酶 1（SOD1）、脂质过氧化物（LOOH）、一氧化氮代谢物（NOx）、丙二醛（MDA）和高级氧化蛋白产物（AOPP）的水平，并计算了反映 RONS/NOSTOX 的 z 单位加权综合评分。该研究纳入了 105 名情绪障碍患者、46 名 GAD 患者和 95 名 TUD 患者。
独立于情绪障碍、TUD、性别和 GAD，MetS 与 MDA 和 AOPP 水平升高有关。动脉粥样硬化和胰岛素抵抗（IR）与 NOSTOX 综合评分显著相关。情绪障碍、TUD、GAD、男性和 MetS 独立导致 RONS/NOSTOX 增加。MetS 的 RONS/NOSTOX 特征与 GAD 不同，后者显示 SOD1 和 NOx 水平升高。TUD 伴有 SOD1、LOOH 和 MDA 增加，而男性则伴有 LOOH 和 AOPP 增加。
MetS 的特点是脂质过氧化增加，形成醛和氯化应激，动脉粥样硬化和 IR 强烈介导 RONS/NOSTOX。部分共享的 RONS/NOSTOX 途径为 MetS 与情绪障碍、GAD 和 TUD 的共病关系提供了基础。
