Lee Han Rim, Song Yun-Mi, Jeon Keun Hye, Cho In Young
Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Department of Family Medicine, CHA Gumi Medical Center, CHA University, Gumi, Korea.
Korean J Fam Med. 2021 Jul;42(4):317-326. doi: 10.4082/kjfm.20.0184. Epub 2021 Jul 20.
Dietary supplements (DS) use is known to be common among cancer survivors. However, detailed information on the factors influencing DS use seems insufficient, including cancer-related and psychological factors.
Study subjects were 1,852 Korean adult cancer survivors recruited from cancer survivor clinic of two university-affiliated hospitals. Data were collected retrospectively through review of medical records and self-administered questionnaires. Psychological factors were assessed using Hospital Anxiety and Depression Scale (HADS) and Fear of Cancer Recurrence Inventory-Short Form. Factors associated the DS use were evaluated by multiple logistic regression analysis after adjusting for covariates.
The prevalence of long-term DS use was 15.7% in overall (17.5% in female and 11.6% in male). Female survivors were 3.14 times (95% confidence interval [CI], 1.89-5.22) more likely to use DS than male. In male cancer survivors, ever-smoking and previous radiotherapy were positively associated with DS use. In females, breast cancer survivors were 0.32 times less likely to use DS compared with stomach cancer survivors, and survivors with family history of cancer were 1.39 times more likely to use DS than those without. After adjusting for sociodemographic, clinical, and lifestyle factors, survivors with anxiety (HADS ≥8) used DS 1.38 times (95% CI, 1.01-1.91) more frequently, compared with those without anxiety.
Diverse factors such as female sex, cancer treatment modality, smoking history, family history and anxiety status were associated with DS use in Korean cancer survivors. Targeted strategies with consideration of these factors are needed for counseling DS use for cancer survivors.
已知膳食补充剂（DS）在癌症幸存者中使用普遍。然而，关于影响DS使用的因素的详细信息似乎不足，包括与癌症相关的因素和心理因素。
研究对象为从两家大学附属医院的癌症幸存者诊所招募的1852名韩国成年癌症幸存者。通过查阅病历和自行填写问卷进行回顾性数据收集。使用医院焦虑抑郁量表（HADS）和癌症复发恐惧量表简表评估心理因素。在调整协变量后，通过多元逻辑回归分析评估与DS使用相关的因素。
总体长期DS使用率为15.7%（女性为17.5%，男性为11.6%）。女性幸存者使用DS的可能性是男性的3.14倍（95%置信区间[CI]，1.89 - 5.22）。在男性癌症幸存者中，曾经吸烟和既往接受放疗与DS使用呈正相关。在女性中，乳腺癌幸存者使用DS的可能性比胃癌幸存者低0.32倍，有癌症家族史的幸存者使用DS的可能性比没有家族史的幸存者高1.39倍。在调整社会人口统计学、临床和生活方式因素后，焦虑（HADS≥8）的幸存者使用DS的频率比无焦虑者高1.38倍（95% CI，1.01 - 1.91）。
女性性别、癌症治疗方式、吸烟史、家族史和焦虑状态等多种因素与韩国癌症幸存者使用DS有关。为癌症幸存者提供关于DS使用的咨询需要考虑这些因素制定有针对性的策略。
