Kim Ji Soo, Oh Seung-Won, Kim Jiwoo
Department of Family Medicine, Seoul National University Hospital, Seoul, Korea.
Department of Family Medicine, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea.
Korean J Fam Med. 2021 Jul;42(4):327-333. doi: 10.4082/kjfm.20.0182. Epub 2021 Jul 20.
Milk consumption is associated with bone mineral density (BMD), but reports are limited in terms of participant age, sex, and number of study subjects. We investigated the association between milk consumption and BMD in South Korean adults (≥20 years).
We analyzed men and women aged ≥20 years who participated in the Korean National Health and Nutrition Examination Survey, 2008-2011. We used linear regression to calculate the mean BMD and 95% confidence interval (CI) based on the frequency of milk consumption. Multivariate logistic regression analysis was used to estimate the odds ratios (ORs) and 95% CI for T-scores ≤-2.5 (osteoporosis) in both men aged ≥50 years and postmenopausal women.
In total 8,539 subjects were studied. Drinking milk more than once a day was associated with higher BMD in the total femur and femoral neck in men aged <50 years and lumbar spine in men aged ≥50 years, compared to less than once a week. It was also associated with lower ORs for osteoporosis of the femoral neck and lumbar spine in men aged ≥50 years (OR, 0.35; 95% CI, 0.125-0.979 and OR, 0.34; 95% CI, 0.143-0.804, respectively). In postmenopausal women who consumed milk 2-6 times weekly, higher BMD and lower OR for osteoporosis were observed in the total femur (OR, 0.23; 95% CI, 0.055-0.958).
This study suggests that frequent milk consumption could potentially reduce osteoporosis incidence in South Korean adults. Further prospective study is necessary to elucidate the effect of milk consumption on BMD.
牛奶摄入量与骨矿物质密度(BMD)相关,但关于参与者年龄、性别和研究对象数量的报告有限。我们调查了韩国成年人(≥20岁)牛奶摄入量与BMD之间的关联。
我们分析了参加2008 - 2011年韩国国家健康与营养检查调查的年龄≥20岁的男性和女性。我们使用线性回归根据牛奶消费频率计算平均BMD和95%置信区间(CI)。多因素逻辑回归分析用于估计≥50岁男性和绝经后女性T分数≤ - 2.5(骨质疏松症)的优势比(OR)和95% CI。
总共研究了8539名受试者。与每周饮用牛奶少于一次相比,每天饮用牛奶超过一次与<50岁男性的全股骨和股骨颈以及≥50岁男性的腰椎BMD较高相关。它还与≥50岁男性股骨颈和腰椎骨质疏松症的较低OR相关(OR分别为0.35;95% CI为0.125 - 0.979和OR为0.34;95% CI为0.143 - 0.804)。在每周饮用牛奶2 - 6次的绝经后女性中,全股骨观察到较高的BMD和较低的骨质疏松症OR(OR为0.23;95% CI为0.055 - 0.958)。
本研究表明,频繁饮用牛奶可能会降低韩国成年人骨质疏松症的发病率。需要进一步的前瞻性研究来阐明牛奶消费对BMD的影响。