Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea.
J Clin Endocrinol Metab. 2012 Sep;97(9):3310-8. doi: 10.1210/jc.2012-1488. Epub 2012 Jun 14.
Bone loss is considered to begin with menopause in women and later in life in men; however, several recent studies have reported that bone loss began in young adults. There are still discordant results concerning age-related changes in bone mineral density (BMD), especially in nonvertebral bone.
The objective of the study was to investigate the age-related changes in BMD in Korean youth.
This was a population-based, cross-sectional study from the Fourth Korea National Health and Nutrition Examination Surveys.
A total 10,575 Korean (4,731 males and 5,844 females) aged 10-80 yr were included.
BMD at the spine and hip was measured using dual X-ray absorptiometry.
Age-related bone loss at the femoral neck in males occurred continuously with temporary acceleration phase after achieving peak bone mass (PBM). In contrast, age-related bone loss at total hip in both sexes and femoral neck in females showed three obvious phases: acceleration, consolidation, and then the second acceleration phase after reaching PBM. Interestingly, this pattern of bone loss was more significant in the total hip and thus showed the acceleration phase until the late 20s and the consolidation phase until the late 40s. Early accelerated loss of BMD was not observed at the lumbar spine in each sex. Although body mass index and body fat percentage were more related with BMD than other clinical parameters, they could not explain the early accelerated loss of BMD at the femur.
There was an accelerated bone loss at the femur in both sexes during early adulthood and more than 60% of the bone loss before age 50 yr occurred during this period.
人们认为女性的骨质流失始于更年期，男性则在更晚的年龄出现骨质流失；然而，最近的几项研究报告称，骨质流失在年轻人中就已经开始了。关于与年龄相关的骨密度（BMD）变化，尤其是非脊椎骨，仍存在不一致的结果。
本研究旨在调查韩国年轻人的 BMD 与年龄的相关性变化。
这是一项基于人群的横断面研究，数据来自第四次韩国国家健康和营养检查调查。
共纳入 10575 名韩国人（4731 名男性和 5844 名女性），年龄在 10-80 岁之间。
使用双能 X 射线吸收法测量脊柱和髋部的 BMD。
男性的股骨颈与年龄相关的骨质流失呈连续下降趋势，在达到峰值骨量（PBM）后出现暂时加速阶段。相比之下，两性的全髋骨和女性的股骨颈与年龄相关的骨质流失呈现出三个明显的阶段：加速、巩固，然后在达到 PBM 后出现第二个加速阶段。有趣的是，这种骨质流失模式在全髋骨中更为显著，因此在 20 多岁后期和 40 多岁后期出现加速阶段和巩固阶段。在每个性别中，腰椎都没有观察到早期的 BMD 加速丢失。尽管体重指数和体脂百分比与 BMD 的相关性比其他临床参数更强，但它们无法解释股骨的早期加速性 BMD 丢失。
两性的股骨在成年早期都有加速性骨质流失，超过 60%的 50 岁前骨质流失发生在这个时期。
