Fischer E, Pfeifenroth A, Varga F
Institute of Pharmacology, University Medical School, Pécs, Hungary.
Pol J Pharmacol Pharm. 1987 Mar-Apr;39(2):147-52.
The role of plasma and liver concentrations of exogenous organic anions and the significance of biotransformation of bromsulfphthalein (BSP) in the biliary excretion rate have been studied in male Sprague-Dawley rats weighing 200-250 g. No parallelism was found between plasma concentration and liver concentration after administration of the same dose of drugs to bile duct-ligated rats. A comparison of the values of hepatic concentration with the biliary excretion rate of drugs seemed to show a negative correlation between these parameters. Biotransformation of BSP (conjugation with glutathione) plays an important role in the biliary excretion of this drug, because the pharmacokinetic parameters of conjugated BSP are quite different from those of unconjugated BSP.
在体重为200 - 250克的雄性斯普拉格 - 道利大鼠中，研究了外源性有机阴离子的血浆和肝脏浓度的作用以及溴磺酞（BSP）生物转化在胆汁排泄率中的意义。给胆管结扎的大鼠施用相同剂量的药物后，血浆浓度和肝脏浓度之间未发现平行关系。肝脏浓度值与药物胆汁排泄率的比较似乎表明这些参数之间呈负相关。BSP的生物转化（与谷胱甘肽结合）在该药物的胆汁排泄中起重要作用，因为结合型BSP的药代动力学参数与未结合型BSP的药代动力学参数有很大不同。
