Donahue R P, Orchard T J, Stein E A, Kuller L H
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261.
Prev Med. 1987 Nov;16(6):796-802. doi: 10.1016/0091-7435(87)90019-3.
The relationship between coffee consumption and lipoprotein lipids and apolipoproteins was examined in 472 white men and women (20-24 years of age) in Beaver County, Pennsylvania, during 1981-1982. Coffee intake, expressed as nondrinker, one to two cups per day, and three or more cups per day, was unrelated to total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, or apoproteins AI, AII, or B. After covariate adjustment for cigarette smoking, alcohol intake, body mass index, and adherence to a diet low in cholesterol and saturated fat, the results remained essentially unchanged. The only statistically significant finding was that women who consumed three or more cups of coffee per day had significantly lower triglyceride concentrations compared with coffee nondrinkers (P less than 0.05). Thus, these findings fail to substantiate a significant association of low to moderate coffee intake with an increased lipid and apoprotein risk profile in these young adults.
1981年至1982年期间,在宾夕法尼亚州比弗县对472名20至24岁的白人男性和女性进行了咖啡摄入量与脂蛋白脂质及载脂蛋白之间关系的研究。咖啡摄入量分为不饮用者、每天饮用1至2杯以及每天饮用3杯及以上,其与总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇或载脂蛋白AI、AII或B均无关联。在对吸烟、酒精摄入量、体重指数以及坚持低胆固醇和饱和脂肪饮食进行协变量调整后,结果基本保持不变。唯一具有统计学显著意义的发现是,每天饮用3杯及以上咖啡的女性与不饮用咖啡的女性相比,甘油三酯浓度显著更低(P小于0.05)。因此,这些研究结果未能证实这些年轻人中低至中度咖啡摄入量与脂质和载脂蛋白风险增加之间存在显著关联。