Thelle D S, Arnesen E, Førde O H
N Engl J Med. 1983 Jun 16;308(24):1454-7. doi: 10.1056/NEJM198306163082405.
We examined the relation between coffee consumption and levels of serum total cholesterol, high-density-lipoprotein (HDL) cholesterol, and triglycerides in a population of 7213 women and 7368 men between the ages of 20 and 54 years. Coffee consumption was positively associated with levels of total cholesterol and triglycerides in both sexes and was inversely associated with levels of HDL cholesterol in women. The coffee-cholesterol relation remained strong and statistically significant (P less than 0.0001 in a covariance analysis) after adjustment for age, logarithm of body-mass index, physical activity in leisure time, cigarette smoking, and alcohol consumption. After adjustment for all covariates, the total cholesterol level was 5.56 +/- 0.05 mmol per liter (mean +/- S.E.) in men drinking less than one cup of coffee a day, as compared with 6.23 +/- 0.03 mmol per liter in those consuming more than nine cups a day. The corresponding figures for women were 5.32 +/- 0.05 and 5.92 +/- 0.04 mmol per liter. None of the other variables considered could explain this relation. We conclude that coffee consumption is a major contributor to the variation in levels of total cholesterol.
我们在7213名年龄在20至54岁之间的女性和7368名男性人群中，研究了咖啡摄入量与血清总胆固醇、高密度脂蛋白（HDL）胆固醇以及甘油三酯水平之间的关系。咖啡摄入量与两性的总胆固醇和甘油三酯水平呈正相关，而与女性的HDL胆固醇水平呈负相关。在对年龄、体重指数的对数、休闲时间的身体活动、吸烟和饮酒进行调整后，咖啡与胆固醇的关系仍然很强且具有统计学意义（在协方差分析中P小于0.0001）。在对所有协变量进行调整后，每天饮用少于一杯咖啡的男性总胆固醇水平为5.56±0.05毫摩尔/升（平均值±标准误），而每天饮用超过九杯咖啡的男性为6.23±0.03毫摩尔/升。女性的相应数字分别为5.32±0.05和5.92±0.04毫摩尔/升。所考虑的其他变量均无法解释这种关系。我们得出结论，咖啡摄入量是总胆固醇水平变化的主要因素。
