Braun Attila, Anders Hans-Joachim, Gudermann Thomas, Mammadova-Bach Elmina
Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig-Maximilian-University, Member of the German Center for Lung Research (DZL), Munich, Germany.
Division of Nephrology, Department of Medicine IV, Ludwig-Maximilians-University Hospital, Munich, Germany.
Front Oncol. 2021 Jul 12;11:665534. doi: 10.3389/fonc.2021.665534. eCollection 2021.
Although platelets are critically involved in thrombosis and hemostasis, experimental and clinical evidence indicate that platelets promote tumor progression and metastasis through a wide range of physical and functional interactions between platelets and cancer cells. Thrombotic and thromboembolic events are frequent complications in patients with solid tumors. Hence, cancer modulates platelet function by directly inducing platelet-tumor aggregates and triggering platelet granule release and altering platelet turnover. Also, platelets enhance tumor cell dissemination by activating endothelial cell function and recruiting immune cells to primary and metastatic tumor sites. In this review, we summarize current knowledge on the complex interactions between platelets and tumor cells and the host microenvironment. We also critically discuss the potential of anti-platelet agents for cancer prevention and treatment.
尽管血小板在血栓形成和止血过程中起着关键作用，但实验和临床证据表明，血小板通过与癌细胞之间广泛的物理和功能相互作用促进肿瘤进展和转移。血栓形成和血栓栓塞事件是实体瘤患者常见的并发症。因此，癌症通过直接诱导血小板 - 肿瘤聚集体、触发血小板颗粒释放以及改变血小板更新来调节血小板功能。此外，血小板通过激活内皮细胞功能并将免疫细胞募集到原发性和转移性肿瘤部位来增强肿瘤细胞的播散。在本综述中，我们总结了目前关于血小板与肿瘤细胞以及宿主微环境之间复杂相互作用的知识。我们还批判性地讨论了抗血小板药物在癌症预防和治疗方面的潜力。
